FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069466730> ?p ?o ?g. }

• W2069466730 endingPage "84" @default.
• W2069466730 startingPage "75" @default.
• W2069466730 abstract "PURPOSE: To determine the levels of interleukin 6 (IL-6) and its soluble receptor (sIL-6R) in the aqueous humor (AH) of patients with different uveitis entities. PATIENTS AND METHODS: AH and serum samples were collected from 35 patients (39 eyes) who underwent surgery for uveitis complications and from 10 controls (senile cataract). In the studied group, seven patients had HLA-B27 + anterior uveitis, two had Fuchs' heterochromic iridocyclitis, 12 had chronic anterior uveitis of unknown etiology, and in the remaining 14 the causative agent was exogenous. The cytokine and receptor levels were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: In controls, the median IL-6 level in AH was higher than that in corresponding sera (40.4 pg/ml and 5.2 pg/ml, respectively). In contrast, sIL-6R showed an inverse relation: there were less sIL-6R in control AH than in control sera (378.9 pg/ml and 52749.0 pg/ml, respectively). The same qualitative relationship was observed in patients with uveitis. Quantitatively, in comparison to controls, elevated levels of IL-6 and sIL-6R were found in AH of patients with uveitis. As expected, the maximal IL-6 and sIL-6R values were observed in the patients with uveitis of exogenous etiology (1558.3 and 1326.2 pg/ml, respectively). sIL-6R was also significantly elevated in AH of patients with HLA-B27 + anterior uveitis (p<0.01). In all individuals under study, sIL-6R levels in AH samples were 2-10 times higher than IL-6 levels. In serum samples, sIL-6R level were 10000 times higher than corresponding IL-6 values. CONCLUSION: The results confirmed the role of IL-6 in intraocular inflammation and gave new information regarding the presence of its sR in normal and inflamed eyes. Low levels of sIL-6R in AH compared to those found in serum suggest the presence of active local regulatory mechanisms that require further investigation." @default.
• W2069466730 created "2016-06-24" @default.
• W2069466730 creator A5069160167 @default.
• W2069466730 creator A5076222135 @default.
• W2069466730 creator A5078815713 @default.
• W2069466730 creator A5080350709 @default.
• W2069466730 creator A5088358210 @default.
• W2069466730 date "1999-01-01" @default.
• W2069466730 modified "2023-09-26" @default.
• W2069466730 title "Interleukin 6 and its soluble receptor are elevated in aqueous humor of patients with uveitis" @default.
• W2069466730 cites W1602943807 @default.
• W2069466730 cites W1991891818 @default.
• W2069466730 cites W1996548067 @default.
• W2069466730 cites W2021310874 @default.
• W2069466730 cites W2025112232 @default.
• W2069466730 cites W2060135531 @default.
• W2069466730 cites W2065700273 @default.
• W2069466730 cites W2081639106 @default.
• W2069466730 cites W2135392289 @default.
• W2069466730 doi "https://doi.org/10.1076/ocii.7.2.75.4017" @default.
• W2069466730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10420202" @default.
• W2069466730 hasPublicationYear "1999" @default.
• W2069466730 type Work @default.
• W2069466730 sameAs 2069466730 @default.
• W2069466730 citedByCount "26" @default.
• W2069466730 countsByYear W20694667302013 @default.
• W2069466730 countsByYear W20694667302014 @default.
• W2069466730 countsByYear W20694667302015 @default.
• W2069466730 countsByYear W20694667302016 @default.
• W2069466730 countsByYear W20694667302017 @default.
• W2069466730 countsByYear W20694667302018 @default.
• W2069466730 countsByYear W20694667302019 @default.
• W2069466730 countsByYear W20694667302020 @default.
• W2069466730 countsByYear W20694667302022 @default.
• W2069466730 crossrefType "journal-article" @default.
• W2069466730 hasAuthorship W2069466730A5069160167 @default.
• W2069466730 hasAuthorship W2069466730A5076222135 @default.
• W2069466730 hasAuthorship W2069466730A5078815713 @default.
• W2069466730 hasAuthorship W2069466730A5080350709 @default.
• W2069466730 hasAuthorship W2069466730A5088358210 @default.
• W2069466730 hasConcept C118487528 @default.
• W2069466730 hasConcept C126322002 @default.
• W2069466730 hasConcept C137627325 @default.
• W2069466730 hasConcept C2776148792 @default.
• W2069466730 hasConcept C2776194053 @default.
• W2069466730 hasConcept C2776713392 @default.
• W2069466730 hasConcept C2778690821 @default.
• W2069466730 hasConcept C2993390227 @default.
• W2069466730 hasConcept C71924100 @default.
• W2069466730 hasConcept C90924648 @default.
• W2069466730 hasConceptScore W2069466730C118487528 @default.
• W2069466730 hasConceptScore W2069466730C126322002 @default.
• W2069466730 hasConceptScore W2069466730C137627325 @default.
• W2069466730 hasConceptScore W2069466730C2776148792 @default.
• W2069466730 hasConceptScore W2069466730C2776194053 @default.
• W2069466730 hasConceptScore W2069466730C2776713392 @default.
• W2069466730 hasConceptScore W2069466730C2778690821 @default.
• W2069466730 hasConceptScore W2069466730C2993390227 @default.
• W2069466730 hasConceptScore W2069466730C71924100 @default.
• W2069466730 hasConceptScore W2069466730C90924648 @default.
• W2069466730 hasIssue "2" @default.
• W2069466730 hasLocation W20694667301 @default.
• W2069466730 hasLocation W20694667302 @default.
• W2069466730 hasOpenAccess W2069466730 @default.
• W2069466730 hasPrimaryLocation W20694667301 @default.
• W2069466730 hasRelatedWork W183123455 @default.
• W2069466730 hasRelatedWork W2307433251 @default.
• W2069466730 hasRelatedWork W2403337683 @default.
• W2069466730 hasRelatedWork W2417522091 @default.
• W2069466730 hasRelatedWork W3010933074 @default.
• W2069466730 hasRelatedWork W3213005815 @default.
• W2069466730 hasRelatedWork W4205988269 @default.
• W2069466730 hasRelatedWork W4250682726 @default.
• W2069466730 hasRelatedWork W4284701750 @default.
• W2069466730 hasRelatedWork W639613333 @default.
• W2069466730 hasVolume "7" @default.
• W2069466730 isParatext "false" @default.
• W2069466730 isRetracted "false" @default.
• W2069466730 magId "2069466730" @default.
• W2069466730 workType "article" @default.