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• W2069478097 abstract "1 The present studies examined the effect of (a) a specific endopeptidase-24.11 (E-24.11) inhibitor (candoxatrilat) and (b) a ligand for the atrial natriuretic peptide (ANP) clearance receptor (SC 46542) on the renal and blood pressure response to brain natriuretic peptide (BNP) in conscious rats. 2 Infusion of BNP 200 ng kg−1 min−1 for 60 min produced a small rise in urinary sodium and guanosine 3′:5′-cyclic monophosphate (cyclic GMP) excretion with a non-significant fall in mean arterial blood pressure. 3 Candoxatrilat (3 mg kg−1) alone had no significant effect on sodium excretion or blood pressure but markedly potentiated the natriuretic response to BNP. 4 Similarly SC 46542 (68 μg kg−1; 6.8 μg kg−1 min−1) which produced no significant effect on its own, potentiated the natriuresis-induced by BNP, although the effect was of shorter duration compared to that of candoxatrilat. 5 The data indicate two approaches to the potentiation of the renal activity of BNP and suggest that BNP may mediate some of the activity of E-24.11 inhibitors reported in cardiac failure." @default.
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• W2069478097 date "1993-09-01" @default.
• W2069478097 modified "2023-09-25" @default.
• W2069478097 title "Effect of endopeptidase-24.11 inhibition and of atrial natriuretic peptide clearance receptor ligand on the response to rat brain natriuretic peptide in the conscious rat" @default.
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• W2069478097 doi "https://doi.org/10.1111/j.1476-5381.1993.tb13816.x" @default.
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