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- W2069482968 abstract "In vivo and in vitro studies of the effectiveness of WR-2721 (aminopropylaminoethylphosphorothioic acid) as a radioprotective drug are reviewed. Because WR-2721 is a very hydrophilic drug, it has difficulty crossing the membranes of most solid tumor cells and of red blood cells. Since most standard radioprotectants are less hydrophilic, this explains why WR-2721 can selectively protect normal tissues against radiation injury while leaving solid tumors unprotected. Biophysical studies reviewed include those dealing with the partition coefficient and pH sensitivity. The future direction of studies such as these should be toward optimizing the clinical application of WR-2721 and of identifying newer and more effective radioprotective agents. (KRM)" @default.
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- W2069482968 title "Protective drugs in cancer therapy: Optimal clinical testing and future directions" @default.
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- W2069482968 doi "https://doi.org/10.1016/0360-3016(82)90673-3" @default.
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