FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069488321> ?p ?o ?g. }

• W2069488321 endingPage "3400" @default.
• W2069488321 startingPage "3394" @default.
• W2069488321 abstract "Substituted pyrazinoic acid esters have previously been reported to have in vitro activity against Mycobacterium avium and Mycobacterium kansasii as well as Mycobacterium tuberculosis. Modification of both the pyrazine nucleus and the ester functionality was successful in expanding the antimycobacterial activity associated with pyrazinamide to include M. avium and M. kansasii, organisms usually not susceptible to pyrazinamide. In an attempt to understand the relationship between the activity of the esters with the needed biostability, a quantitative structure-activity relationship has been developed. This derived relationship is consistent with the observation that tert-butyl 5-chloropyrazinoate (13) and 2'-(2'-methyldecyl) 5-chloropyrazinoate (25), compounds which are both 100-fold more active than pyrazinamide against M. tuberculosis and possess a serum stability 900-1000 times greater than the lead compounds in the series." @default.
• W2069488321 created "2016-06-24" @default.
• W2069488321 creator A5030141303 @default.
• W2069488321 creator A5053265147 @default.
• W2069488321 creator A5066867417 @default.
• W2069488321 date "1996-01-01" @default.
• W2069488321 modified "2023-10-01" @default.
• W2069488321 title "Quantitative Structure−Activity Relationships for the <i>in Vitro</i> Antimycobacterial Activity of Pyrazinoic Acid Esters" @default.
• W2069488321 cites W1966814641 @default.
• W2069488321 cites W1971664672 @default.
• W2069488321 cites W2003610617 @default.
• W2069488321 cites W2052008210 @default.
• W2069488321 cites W2312626454 @default.
• W2069488321 cites W2321929586 @default.
• W2069488321 cites W2324686585 @default.
• W2069488321 cites W2329340339 @default.
• W2069488321 cites W2333765171 @default.
• W2069488321 cites W2949632495 @default.
• W2069488321 cites W2951763822 @default.
• W2069488321 cites W3005020879 @default.
• W2069488321 doi "https://doi.org/10.1021/jm950538t" @default.
• W2069488321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8765523" @default.
• W2069488321 hasPublicationYear "1996" @default.
• W2069488321 type Work @default.
• W2069488321 sameAs 2069488321 @default.
• W2069488321 citedByCount "55" @default.
• W2069488321 countsByYear W20694883212012 @default.
• W2069488321 countsByYear W20694883212013 @default.
• W2069488321 countsByYear W20694883212014 @default.
• W2069488321 countsByYear W20694883212015 @default.
• W2069488321 countsByYear W20694883212016 @default.
• W2069488321 countsByYear W20694883212017 @default.
• W2069488321 countsByYear W20694883212018 @default.
• W2069488321 countsByYear W20694883212019 @default.
• W2069488321 countsByYear W20694883212020 @default.
• W2069488321 countsByYear W20694883212021 @default.
• W2069488321 countsByYear W20694883212022 @default.
• W2069488321 crossrefType "journal-article" @default.
• W2069488321 hasAuthorship W2069488321A5030141303 @default.
• W2069488321 hasAuthorship W2069488321A5053265147 @default.
• W2069488321 hasAuthorship W2069488321A5066867417 @default.
• W2069488321 hasConcept C116073593 @default.
• W2069488321 hasConcept C142724271 @default.
• W2069488321 hasConcept C185592680 @default.
• W2069488321 hasConcept C193042331 @default.
• W2069488321 hasConcept C202751555 @default.
• W2069488321 hasConcept C2777975735 @default.
• W2069488321 hasConcept C2778607973 @default.
• W2069488321 hasConcept C2779685592 @default.
• W2069488321 hasConcept C2780374374 @default.
• W2069488321 hasConcept C2780459521 @default.
• W2069488321 hasConcept C2780931024 @default.
• W2069488321 hasConcept C2781069245 @default.
• W2069488321 hasConcept C3019249092 @default.
• W2069488321 hasConcept C501593827 @default.
• W2069488321 hasConcept C55493867 @default.
• W2069488321 hasConcept C71240020 @default.
• W2069488321 hasConcept C71924100 @default.
• W2069488321 hasConcept C86803240 @default.
• W2069488321 hasConcept C89423630 @default.
• W2069488321 hasConcept C98274493 @default.
• W2069488321 hasConceptScore W2069488321C116073593 @default.
• W2069488321 hasConceptScore W2069488321C142724271 @default.
• W2069488321 hasConceptScore W2069488321C185592680 @default.
• W2069488321 hasConceptScore W2069488321C193042331 @default.
• W2069488321 hasConceptScore W2069488321C202751555 @default.
• W2069488321 hasConceptScore W2069488321C2777975735 @default.
• W2069488321 hasConceptScore W2069488321C2778607973 @default.
• W2069488321 hasConceptScore W2069488321C2779685592 @default.
• W2069488321 hasConceptScore W2069488321C2780374374 @default.
• W2069488321 hasConceptScore W2069488321C2780459521 @default.
• W2069488321 hasConceptScore W2069488321C2780931024 @default.
• W2069488321 hasConceptScore W2069488321C2781069245 @default.
• W2069488321 hasConceptScore W2069488321C3019249092 @default.
• W2069488321 hasConceptScore W2069488321C501593827 @default.
• W2069488321 hasConceptScore W2069488321C55493867 @default.
• W2069488321 hasConceptScore W2069488321C71240020 @default.
• W2069488321 hasConceptScore W2069488321C71924100 @default.
• W2069488321 hasConceptScore W2069488321C86803240 @default.
• W2069488321 hasConceptScore W2069488321C89423630 @default.
• W2069488321 hasConceptScore W2069488321C98274493 @default.
• W2069488321 hasIssue "17" @default.
• W2069488321 hasLocation W20694883211 @default.
• W2069488321 hasLocation W20694883212 @default.
• W2069488321 hasOpenAccess W2069488321 @default.
• W2069488321 hasPrimaryLocation W20694883211 @default.
• W2069488321 hasRelatedWork W1971664672 @default.
• W2069488321 hasRelatedWork W2006679073 @default.
• W2069488321 hasRelatedWork W2024387486 @default.
• W2069488321 hasRelatedWork W2048594000 @default.
• W2069488321 hasRelatedWork W2052120566 @default.
• W2069488321 hasRelatedWork W2069488321 @default.
• W2069488321 hasRelatedWork W2118270242 @default.
• W2069488321 hasRelatedWork W2153527675 @default.
• W2069488321 hasRelatedWork W2408764516 @default.
• W2069488321 hasRelatedWork W2949632495 @default.
• W2069488321 hasVolume "39" @default.
• W2069488321 isParatext "false" @default.

• next