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• W2069492032 endingPage "399" @default.
• W2069492032 startingPage "396" @default.
• W2069492032 abstract "The cryptochrome/photolyase (CRY/PL) family of photoreceptors mediates adaptive responses to ultraviolet and blue light exposure in all kingdoms of life. Whereas PLs function predominantly in DNA repair of cyclobutane pyrimidine dimers (CPDs) and 6-4 photolesions caused by ultraviolet radiation, CRYs transduce signals important for growth, development, magnetosensitivity and circadian clocks. Despite these diverse functions, PLs/CRYs preserve a common structural fold, a dependence on flavin adenine dinucleotide (FAD) and an internal photoactivation mechanism. However, members of the CRY/PL family differ in the substrates recognized (protein or DNA), photochemical reactions catalysed and involvement of an antenna cofactor. It is largely unknown how the animal CRYs that regulate circadian rhythms act on their substrates. CRYs contain a variable carboxy-terminal tail that appends the conserved PL homology domain (PHD) and is important for function. Here, we report a 2.3-Å resolution crystal structure of Drosophila CRY with an intact C terminus. The C-terminal helix docks in the analogous groove that binds DNA substrates in PLs. Conserved Trp 536 juts into the CRY catalytic centre to mimic PL recognition of DNA photolesions. The FAD anionic semiquinone found in the crystals assumes a conformation to facilitate restructuring of the tail helix. These results help reconcile the diverse functions of the CRY/PL family by demonstrating how conserved protein architecture and photochemistry can be elaborated into a range of light-driven functions." @default.
• W2069492032 created "2016-06-24" @default.
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• W2069492032 date "2011-11-13" @default.
• W2069492032 modified "2023-09-29" @default.
• W2069492032 title "Structure of full-length Drosophila cryptochrome" @default.
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• W2069492032 doi "https://doi.org/10.1038/nature10618" @default.
• W2069492032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3240699" @default.
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• W2069492032 hasPublicationYear "2011" @default.
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