FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069492079> ?p ?o ?g. }

• W2069492079 endingPage "1232" @default.
• W2069492079 startingPage "1224" @default.
• W2069492079 abstract "Abstract The potential role of 4‐hydroxynonenal (HNE), a major product of membrane lipid peroxidation, in regulating glycogen synthase kinase‐3β (GSK3β) activity was examined in human neuroblastoma IMR‐32 cells. The inhibition of GSK3β activity by HNE was observed by in vitro kinase assays with two substrates, the synthetic glycogen synthase peptide‐2 and the human recombinant tau. GSK3β activity is regulated by Ser9 (inhibitory) and Tyr216 (stimulatory) phosphorylation. By using specific activity‐dependent phospho‐antibodies, immunoblot analysis revealed that HNE induces an increase in phosphorylation of GSK3β in Ser9, enhancing basal phosphatidylinositol 3‐kinase (PI3K)/AKT and extracellular signal‐regulated kinase 2 (ERK2) signalling pathways. Ser9‐GSK3β phosphorylation induced by HNE was abolished by treatment with LY294002 or U0126, two inhibitors of PI3K/AKT and ERK pathways, respectively. These experiments provide evidence for a crucial role of the PI3K/AKT and ERK2 pathways as intracellular targets of HNE that mediate the inhibition of GSK3β activity in regulating cellular response to HNE in viable cells under conditions in which membrane lipid peroxidation occurs. These data support a key role for GSK3β as a mediator of the signalling pathways activated by oxidative stress, and therefore it may be included among the redox‐sensitive enzymes." @default.
• W2069492079 created "2016-06-24" @default.
• W2069492079 creator A5021160692 @default.
• W2069492079 creator A5021420538 @default.
• W2069492079 creator A5060420616 @default.
• W2069492079 creator A5075477128 @default.
• W2069492079 creator A5088261494 @default.
• W2069492079 date "2004-04-29" @default.
• W2069492079 modified "2023-10-12" @default.
• W2069492079 title "Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells" @default.
• W2069492079 cites W1494495256 @default.
• W2069492079 cites W1496314348 @default.
• W2069492079 cites W1510592624 @default.
• W2069492079 cites W1518972222 @default.
• W2069492079 cites W1532078866 @default.
• W2069492079 cites W1581358998 @default.
• W2069492079 cites W1596652845 @default.
• W2069492079 cites W1811191752 @default.
• W2069492079 cites W1908612571 @default.
• W2069492079 cites W1965638587 @default.
• W2069492079 cites W1974198922 @default.
• W2069492079 cites W1984856280 @default.
• W2069492079 cites W1984890353 @default.
• W2069492079 cites W1991480450 @default.
• W2069492079 cites W1993174592 @default.
• W2069492079 cites W1994151063 @default.
• W2069492079 cites W1997307819 @default.
• W2069492079 cites W2002232151 @default.
• W2069492079 cites W2004078164 @default.
• W2069492079 cites W2004972907 @default.
• W2069492079 cites W2008308614 @default.
• W2069492079 cites W2012394888 @default.
• W2069492079 cites W2017592134 @default.
• W2069492079 cites W2022658303 @default.
• W2069492079 cites W2031864556 @default.
• W2069492079 cites W2043085415 @default.
• W2069492079 cites W2045012491 @default.
• W2069492079 cites W2046431926 @default.
• W2069492079 cites W2047841570 @default.
• W2069492079 cites W2053174155 @default.
• W2069492079 cites W2053265248 @default.
• W2069492079 cites W2054223500 @default.
• W2069492079 cites W2058138221 @default.
• W2069492079 cites W2061699263 @default.
• W2069492079 cites W2062934426 @default.
• W2069492079 cites W2065718536 @default.
• W2069492079 cites W2069787626 @default.
• W2069492079 cites W2083117403 @default.
• W2069492079 cites W2085931606 @default.
• W2069492079 cites W2086450927 @default.
• W2069492079 cites W2088894802 @default.
• W2069492079 cites W2112740682 @default.
• W2069492079 cites W2122709827 @default.
• W2069492079 cites W2125904354 @default.
• W2069492079 cites W2132083914 @default.
• W2069492079 cites W2147993424 @default.
• W2069492079 cites W2151848842 @default.
• W2069492079 cites W2172249877 @default.
• W2069492079 cites W2184250922 @default.
• W2069492079 cites W4256264762 @default.
• W2069492079 cites W65155625 @default.
• W2069492079 doi "https://doi.org/10.1111/j.1471-4159.2004.02413.x" @default.
• W2069492079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15147515" @default.
• W2069492079 hasPublicationYear "2004" @default.
• W2069492079 type Work @default.
• W2069492079 sameAs 2069492079 @default.
• W2069492079 citedByCount "40" @default.
• W2069492079 countsByYear W20694920792012 @default.
• W2069492079 countsByYear W20694920792014 @default.
• W2069492079 countsByYear W20694920792015 @default.
• W2069492079 countsByYear W20694920792016 @default.
• W2069492079 countsByYear W20694920792017 @default.
• W2069492079 countsByYear W20694920792018 @default.
• W2069492079 countsByYear W20694920792019 @default.
• W2069492079 countsByYear W20694920792020 @default.
• W2069492079 countsByYear W20694920792021 @default.
• W2069492079 crossrefType "journal-article" @default.
• W2069492079 hasAuthorship W2069492079A5021160692 @default.
• W2069492079 hasAuthorship W2069492079A5021420538 @default.
• W2069492079 hasAuthorship W2069492079A5060420616 @default.
• W2069492079 hasAuthorship W2069492079A5075477128 @default.
• W2069492079 hasAuthorship W2069492079A5088261494 @default.
• W2069492079 hasBestOaLocation W20694920791 @default.
• W2069492079 hasConcept C104629339 @default.
• W2069492079 hasConcept C11960822 @default.
• W2069492079 hasConcept C182996813 @default.
• W2069492079 hasConcept C184235292 @default.
• W2069492079 hasConcept C185592680 @default.
• W2069492079 hasConcept C192118531 @default.
• W2069492079 hasConcept C2776151105 @default.
• W2069492079 hasConcept C2779308327 @default.
• W2069492079 hasConcept C2780829032 @default.
• W2069492079 hasConcept C55493867 @default.
• W2069492079 hasConcept C57074206 @default.
• W2069492079 hasConcept C62478195 @default.
• W2069492079 hasConcept C75217442 @default.
• W2069492079 hasConcept C86554907 @default.
• W2069492079 hasConcept C86803240 @default.

• next