FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069492714> ?p ?o ?g. }

• W2069492714 abstract "Ion-driven ATP synthesis by rotary F0F1 ATP-synthase powers aerobic life. Since Mitchell's seminal hypothesis, this synthesis has been discussed in terms of the proton-motive force between two bulk phases, each in equilibrium. In active mitochondria, a steady proton flow cycles between pumps and the distant ATP synthase. Here we determine the lateral pH profile along the p-side of cristae in situ by attaching a ratiometric fluorescent pH-sensitive GFP variant to OXPHOS complex IV, a proton pump, and the dimeric F0F1 ATP-synthase, a proton consumer. In respiring HeLa cells, we observe that the local pH at F0F1 dimers is 0.3 units less acidic than that at complex IV. This finding is consistent with the calculated pH profile for steady proton diffusion from CIV to F0F1. The observed lateral variation in the proton-motive force necessitates a modification to Peter Mitchell's chemiosmotic proposal. The experimental technique can be extended to other pH-dependent reactions in membrane microcompartments." @default.
• W2069492714 created "2016-06-24" @default.
• W2069492714 creator A5047927000 @default.
• W2069492714 creator A5065789246 @default.
• W2069492714 creator A5088126118 @default.
• W2069492714 date "2014-01-29" @default.
• W2069492714 modified "2023-10-14" @default.
• W2069492714 title "Lateral pH gradient between OXPHOS complex IV and F0F1 ATP-synthase in folded mitochondrial membranes" @default.
• W2069492714 cites W1483212110 @default.
• W2069492714 cites W1964126982 @default.
• W2069492714 cites W1987695736 @default.
• W2069492714 cites W1993175937 @default.
• W2069492714 cites W1999040292 @default.
• W2069492714 cites W2000285789 @default.
• W2069492714 cites W2001756549 @default.
• W2069492714 cites W2002269806 @default.
• W2069492714 cites W2006578754 @default.
• W2069492714 cites W2016166286 @default.
• W2069492714 cites W2026962576 @default.
• W2069492714 cites W2034207498 @default.
• W2069492714 cites W2057948966 @default.
• W2069492714 cites W2073239775 @default.
• W2069492714 cites W2077996001 @default.
• W2069492714 cites W2079980765 @default.
• W2069492714 cites W2086735769 @default.
• W2069492714 cites W2090734611 @default.
• W2069492714 cites W2100617050 @default.
• W2069492714 cites W2118139638 @default.
• W2069492714 cites W2121110584 @default.
• W2069492714 cites W2128427317 @default.
• W2069492714 cites W2132832649 @default.
• W2069492714 cites W2135593606 @default.
• W2069492714 cites W2137564359 @default.
• W2069492714 cites W2140783672 @default.
• W2069492714 cites W2141260882 @default.
• W2069492714 cites W2153429125 @default.
• W2069492714 cites W2155714127 @default.
• W2069492714 cites W2156832451 @default.
• W2069492714 cites W2162727760 @default.
• W2069492714 cites W2170676142 @default.
• W2069492714 doi "https://doi.org/10.1038/ncomms4103" @default.
• W2069492714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24476986" @default.
• W2069492714 hasPublicationYear "2014" @default.
• W2069492714 type Work @default.
• W2069492714 sameAs 2069492714 @default.
• W2069492714 citedByCount "115" @default.
• W2069492714 countsByYear W20694927142014 @default.
• W2069492714 countsByYear W20694927142015 @default.
• W2069492714 countsByYear W20694927142016 @default.
• W2069492714 countsByYear W20694927142017 @default.
• W2069492714 countsByYear W20694927142018 @default.
• W2069492714 countsByYear W20694927142019 @default.
• W2069492714 countsByYear W20694927142020 @default.
• W2069492714 countsByYear W20694927142021 @default.
• W2069492714 countsByYear W20694927142022 @default.
• W2069492714 countsByYear W20694927142023 @default.
• W2069492714 crossrefType "journal-article" @default.
• W2069492714 hasAuthorship W2069492714A5047927000 @default.
• W2069492714 hasAuthorship W2069492714A5065789246 @default.
• W2069492714 hasAuthorship W2069492714A5088126118 @default.
• W2069492714 hasBestOaLocation W20694927141 @default.
• W2069492714 hasConcept C101692577 @default.
• W2069492714 hasConcept C104317684 @default.
• W2069492714 hasConcept C112243037 @default.
• W2069492714 hasConcept C119120687 @default.
• W2069492714 hasConcept C121332964 @default.
• W2069492714 hasConcept C12554922 @default.
• W2069492714 hasConcept C128892225 @default.
• W2069492714 hasConcept C141315368 @default.
• W2069492714 hasConcept C171357686 @default.
• W2069492714 hasConcept C181199279 @default.
• W2069492714 hasConcept C181911157 @default.
• W2069492714 hasConcept C185592680 @default.
• W2069492714 hasConcept C23265538 @default.
• W2069492714 hasConcept C28859421 @default.
• W2069492714 hasConcept C2992012372 @default.
• W2069492714 hasConcept C41625074 @default.
• W2069492714 hasConcept C54516573 @default.
• W2069492714 hasConcept C55493867 @default.
• W2069492714 hasConcept C57600042 @default.
• W2069492714 hasConcept C62520636 @default.
• W2069492714 hasConcept C686708 @default.
• W2069492714 hasConcept C69305403 @default.
• W2069492714 hasConcept C86803240 @default.
• W2069492714 hasConcept C90424259 @default.
• W2069492714 hasConceptScore W2069492714C101692577 @default.
• W2069492714 hasConceptScore W2069492714C104317684 @default.
• W2069492714 hasConceptScore W2069492714C112243037 @default.
• W2069492714 hasConceptScore W2069492714C119120687 @default.
• W2069492714 hasConceptScore W2069492714C121332964 @default.
• W2069492714 hasConceptScore W2069492714C12554922 @default.
• W2069492714 hasConceptScore W2069492714C128892225 @default.
• W2069492714 hasConceptScore W2069492714C141315368 @default.
• W2069492714 hasConceptScore W2069492714C171357686 @default.
• W2069492714 hasConceptScore W2069492714C181199279 @default.
• W2069492714 hasConceptScore W2069492714C181911157 @default.
• W2069492714 hasConceptScore W2069492714C185592680 @default.
• W2069492714 hasConceptScore W2069492714C23265538 @default.
• W2069492714 hasConceptScore W2069492714C28859421 @default.
• W2069492714 hasConceptScore W2069492714C2992012372 @default.

• next