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• W2069499237 abstract "In Epstein-Barr virus (EBV)-infected BL cells, the oncogenic EBV-encoded nuclear antigen 1 (EBNA 1) gene is directed from the latent promoter Qp. Yeast one-hybrid screen analysis using the -50 to -37 sequence of Qp as the bait was carried out to identify transcriptional factors that may control Qp activity. Results showed that Smad4 binds the -50 to -37 sequence of Qp, indicating that this promoter is potentially regulated by TGF-beta. The association of Smad4 with Qp was further confirmed by supershift of EMSA complexes using Smad4-specific antibody. The transfection of a Qp reporter construct in two EBV(+) BL cell lines, Rael and WW2, showed that Qp activity is repressed in response to the TGF-beta treatment. This repression involves the interaction of a Smad3/Smad4 complex and the transcriptional repressor TGIF, as determined by cotransfection assay and coimmunoprecipitation analysis. Results suggest that TGF-beta may transcriptionally repress Qp through the Smad4-binding site in human BL cells." @default.
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• W2069499237 date "2000-11-01" @default.
• W2069499237 modified "2023-10-14" @default.
• W2069499237 title "Transcription of Epstein–Barr Virus-Encoded Nuclear Antigen 1 Promoter Qp Is Repressed by Transforming Growth Factor-β via Smad4 Binding Element in Human BL Cells" @default.
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• W2069499237 doi "https://doi.org/10.1006/viro.2000.0582" @default.
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