Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069501274> ?p ?o ?g. }
- W2069501274 endingPage "986" @default.
- W2069501274 startingPage "980" @default.
- W2069501274 abstract "Abstract Tissue factor (TF) initiates blood coagulation, but its expression in the vascular space requires a finite period of time. We hypothesized that targeting exogenous tissue factor to sites of vascular injury could lead to accelerated hemostasis. Since phosphatidylserine (PS) is exposed on activated cells at sites of vascular injury, we cloned the cDNA for a chimeric protein consisting of the extracellular domain of TF (called soluble TF or sTF) and annexin V, a human PS-binding protein. Both the sTF and annexin V domains had ligand-binding activities consistent with their native counterparts, and the chimera accelerated factor X activation by factor VIIa. The chimera exhibited biphasic effects upon blood coagulation. At low concentrations it accelerated blood coagulation, while at higher concentrations it acted as an anticoagulant. The chimera accelerated coagulation in the presence of either unfractionated or low-molecular-weight heparins more potently than factor VIIa and shortened the bleeding time of mice treated with enoxaparin. The sTF-annexin V chimera is a targeted procoagulant protein that may be useful in accelerating thrombin generation where PS is exposed to the vasculature, such as may occur at sites of vascular injury or within the vasculature of tumors." @default.
- W2069501274 created "2016-06-24" @default.
- W2069501274 creator A5001123822 @default.
- W2069501274 creator A5003274142 @default.
- W2069501274 creator A5007520892 @default.
- W2069501274 creator A5030347346 @default.
- W2069501274 creator A5058096595 @default.
- W2069501274 creator A5080935177 @default.
- W2069501274 creator A5091908601 @default.
- W2069501274 date "2006-02-01" @default.
- W2069501274 modified "2023-09-28" @default.
- W2069501274 title "A soluble tissue factor-annexin V chimeric protein has both procoagulant and anticoagulant properties" @default.
- W2069501274 cites W128953578 @default.
- W2069501274 cites W1489024269 @default.
- W2069501274 cites W1514947270 @default.
- W2069501274 cites W1519535724 @default.
- W2069501274 cites W1527896649 @default.
- W2069501274 cites W1548004194 @default.
- W2069501274 cites W1594006822 @default.
- W2069501274 cites W1599922256 @default.
- W2069501274 cites W1599975943 @default.
- W2069501274 cites W1608358576 @default.
- W2069501274 cites W1731655839 @default.
- W2069501274 cites W1963731836 @default.
- W2069501274 cites W1971070219 @default.
- W2069501274 cites W1983437144 @default.
- W2069501274 cites W1985342306 @default.
- W2069501274 cites W1987141680 @default.
- W2069501274 cites W1988034658 @default.
- W2069501274 cites W1997521359 @default.
- W2069501274 cites W1997654208 @default.
- W2069501274 cites W1997904070 @default.
- W2069501274 cites W2016657349 @default.
- W2069501274 cites W2024907000 @default.
- W2069501274 cites W2029384648 @default.
- W2069501274 cites W2042177086 @default.
- W2069501274 cites W2044351980 @default.
- W2069501274 cites W2045798059 @default.
- W2069501274 cites W2054434160 @default.
- W2069501274 cites W2063375020 @default.
- W2069501274 cites W2067593747 @default.
- W2069501274 cites W2068490440 @default.
- W2069501274 cites W2081322582 @default.
- W2069501274 cites W2086386188 @default.
- W2069501274 cites W2101605999 @default.
- W2069501274 cites W2126258404 @default.
- W2069501274 cites W2165461731 @default.
- W2069501274 cites W2238231990 @default.
- W2069501274 cites W2423438178 @default.
- W2069501274 cites W344912797 @default.
- W2069501274 cites W67249329 @default.
- W2069501274 doi "https://doi.org/10.1182/blood-2005-07-2733" @default.
- W2069501274 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1895899" @default.
- W2069501274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16195337" @default.
- W2069501274 hasPublicationYear "2006" @default.
- W2069501274 type Work @default.
- W2069501274 sameAs 2069501274 @default.
- W2069501274 citedByCount "21" @default.
- W2069501274 countsByYear W20695012742012 @default.
- W2069501274 countsByYear W20695012742013 @default.
- W2069501274 countsByYear W20695012742015 @default.
- W2069501274 countsByYear W20695012742018 @default.
- W2069501274 countsByYear W20695012742019 @default.
- W2069501274 countsByYear W20695012742021 @default.
- W2069501274 countsByYear W20695012742023 @default.
- W2069501274 crossrefType "journal-article" @default.
- W2069501274 hasAuthorship W2069501274A5001123822 @default.
- W2069501274 hasAuthorship W2069501274A5003274142 @default.
- W2069501274 hasAuthorship W2069501274A5007520892 @default.
- W2069501274 hasAuthorship W2069501274A5030347346 @default.
- W2069501274 hasAuthorship W2069501274A5058096595 @default.
- W2069501274 hasAuthorship W2069501274A5080935177 @default.
- W2069501274 hasAuthorship W2069501274A5091908601 @default.
- W2069501274 hasBestOaLocation W20695012741 @default.
- W2069501274 hasConcept C104317684 @default.
- W2069501274 hasConcept C112516734 @default.
- W2069501274 hasConcept C126322002 @default.
- W2069501274 hasConcept C144594695 @default.
- W2069501274 hasConcept C153911025 @default.
- W2069501274 hasConcept C185592680 @default.
- W2069501274 hasConcept C186738567 @default.
- W2069501274 hasConcept C203014093 @default.
- W2069501274 hasConcept C2776046644 @default.
- W2069501274 hasConcept C2777292125 @default.
- W2069501274 hasConcept C2777444498 @default.
- W2069501274 hasConcept C2778382381 @default.
- W2069501274 hasConcept C2778589496 @default.
- W2069501274 hasConcept C2778918659 @default.
- W2069501274 hasConcept C2779637612 @default.
- W2069501274 hasConcept C2780670749 @default.
- W2069501274 hasConcept C2780868729 @default.
- W2069501274 hasConcept C2781287897 @default.
- W2069501274 hasConcept C30278631 @default.
- W2069501274 hasConcept C30345302 @default.
- W2069501274 hasConcept C41625074 @default.
- W2069501274 hasConcept C553184892 @default.
- W2069501274 hasConcept C55493867 @default.
- W2069501274 hasConcept C71924100 @default.