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• W2069502134 abstract "Four trans-dihydrodiols derived from 7,12-dimethylbenz[a]anthracene have been tested, together with the parent hydrocarbon, for their abilities to induce mutations in V79 Chinese hamster cells and malignant transformations in M2 mouse fibroblasts. Both the 3,4- and the 8,9-diols derived from 7,12-dimethylbenz[a]anthracene induced mutations to 8-azaguanine resistance in V79 cells and malignant transformation in M2 mouse fibroblasts and were more active than the hydrocarbon itself. The K-region 5,6-diol and the non-K-region 10,11-diol were without activity. The biological activity of the 3,4-dihydrodiol is consistent with other data suggesting that the metabolic activation of 7,12-dimethylbenz[a]anthracene occurs through conversion of the 3,4-dihydrodiol into the related vicinal diol-epoxides, but the activity shown by the 8,9-dihydrodiol in these in vitro test systems is not." @default.
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• W2069502134 date "1978-11-01" @default.
• W2069502134 modified "2023-10-16" @default.
• W2069502134 title "Induction of malignant transformation and mutagenesis by dihydrodiols derived from 7,12-dimethylbenz[a]anthracene" @default.
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• W2069502134 doi "https://doi.org/10.1016/s0006-291x(78)80050-3" @default.
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