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- W2069540232 abstract "Background: An escape from the dexamethasone-induced suppression of pituitary–adrenocortical activity can be provoked by corticotropin-releasing hormone (CRH) in depressed patients, but not in healthy controls. One important antagonist of the CRH-stimulated secretion of corticotropin (ACTH) and cortisol is atrial natriuretic hormone (ANH). Methods: To study a potential role of ANH in the dexamethasone-CRH test, we investigated 7 healthy men who did not suppress cortisol below 40 ng/mL after they had received 0.5 mg dexamethasone the evening before. Results: We found 1) that the CRH-stimulated ACTH and cortisol secretion was significantly reduced by the administration of ANH in comparison to saline; and 2) that there was an increased pituitary–adrenocortical ratio. Conclusions: Our results support the view that ANH may also be involved in the frequently observed nonsuppression after dexamethasone during depression." @default.
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- W2069540232 date "1998-03-01" @default.
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- W2069540232 title "Atrial Natriuretic Hormone Decreases Endocrine Response to a Combined Dexamethasone–Corticotropin-Releasing Hormone Test" @default.
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- W2069540232 doi "https://doi.org/10.1016/s0006-3223(97)00200-x" @default.
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