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• W2069540241 abstract "Chronic alcohol use can result in many pathological effects including alcoholic liver disease (ALD). While alcohol is necessary for the development of ALD, only 20-30% of alcoholics develop alcoholic steatohepatitis (ASH) with progressive liver disease leading to cirrhosis and liver failure (ALD). This suggests that while chronic alcohol consumption is necessary it is not sufficient to induce clinically relevant liver damage in the absence of a secondary risk factor. Studies in rodent models and alcoholic patients show that increased intestinal permeability to microbial products like endotoxin play a critical role in promoting liver inflammation in ALD pathogenesis. Therefore identifying mechanisms of alcohol-induced intestinal permeability is important in identifying mechanisms of ALD and for designing new avenues for therapy. Cyp2e1 is a cytochrome P450 enzyme that metabolizes alcohol has been shown to be upregulated by chronic alcohol use and to be a major source of oxidative stress and liver injury in alcoholics and in animal and in vitro models of chronic alcohol use. Because Cyp2e1 is also expressed in the intestine and is upregulated by chronic alcohol use, we hypothesized it could play a role in alcohol-induced intestinal hyperpermeability. Our in vitro studies with intestinal Caco-2 cells and in mice fed alcohol showed that circadian clock proteins CLOCK and PER2 are required for alcohol-induced permeability. We also showed that alcohol increases Cyp2e1 protein and activity but not mRNA in Caco-2 cells and that an inhibitor of oxidative stress or siRNA knockdown of Cyp2e1 prevents the increase in CLOCK or PER2 proteins and prevents alcohol-induced hyperpermeability. With our collaborators we have also shown that Cyp2e1 knockout mice are resistant to alcohol-induced gut leakiness and liver inflammation. Taken together our data support a novel Cyp2e1-circadian clock protein mechanism for alcohol-induced gut leakiness that could provide new avenues for therapy of ALD." @default.
• W2069540241 created "2016-06-24" @default.
• W2069540241 creator A5002619544 @default.
• W2069540241 creator A5062131424 @default.
• W2069540241 creator A5068781763 @default.
• W2069540241 date "2014-01-01" @default.
• W2069540241 modified "2023-10-16" @default.
• W2069540241 title "Intestinal CYP2E1: A mediator of alcohol-induced gut leakiness" @default.
• W2069540241 cites W1356863 @default.
• W2069540241 cites W1559928164 @default.
• W2069540241 cites W1562445183 @default.
• W2069540241 cites W1579719960 @default.
• W2069540241 cites W1650646368 @default.
• W2069540241 cites W1904678284 @default.
• W2069540241 cites W1950443613 @default.
• W2069540241 cites W1965214776 @default.
• W2069540241 cites W1966388865 @default.
• W2069540241 cites W1966598101 @default.
• W2069540241 cites W1969677255 @default.
• W2069540241 cites W1976840757 @default.
• W2069540241 cites W1977429705 @default.
• W2069540241 cites W1979385177 @default.
• W2069540241 cites W1984172120 @default.
• W2069540241 cites W1986300628 @default.
• W2069540241 cites W1986910407 @default.
• W2069540241 cites W1990153938 @default.
• W2069540241 cites W1990856526 @default.
• W2069540241 cites W1990938548 @default.
• W2069540241 cites W1992223744 @default.
• W2069540241 cites W1992669445 @default.
• W2069540241 cites W1995185795 @default.
• W2069540241 cites W2000642498 @default.
• W2069540241 cites W2003302378 @default.
• W2069540241 cites W2006109224 @default.
• W2069540241 cites W2011289267 @default.
• W2069540241 cites W2018257401 @default.
• W2069540241 cites W2021607553 @default.
• W2069540241 cites W2027058093 @default.
• W2069540241 cites W2029493191 @default.
• W2069540241 cites W2030029354 @default.
• W2069540241 cites W2035635857 @default.
• W2069540241 cites W2036951279 @default.
• W2069540241 cites W2038886062 @default.
• W2069540241 cites W2039639342 @default.
• W2069540241 cites W2046582521 @default.
• W2069540241 cites W2048245879 @default.
• W2069540241 cites W2052147433 @default.
• W2069540241 cites W2052579179 @default.
• W2069540241 cites W2053406327 @default.
• W2069540241 cites W2053661184 @default.
• W2069540241 cites W2055973925 @default.
• W2069540241 cites W2060253615 @default.
• W2069540241 cites W2061084936 @default.
• W2069540241 cites W2062065434 @default.
• W2069540241 cites W2062366543 @default.
• W2069540241 cites W2063041018 @default.
• W2069540241 cites W2066357452 @default.
• W2069540241 cites W2070059205 @default.
• W2069540241 cites W2074673544 @default.
• W2069540241 cites W2078923187 @default.
• W2069540241 cites W2083152621 @default.
• W2069540241 cites W2089177264 @default.
• W2069540241 cites W2090975231 @default.
• W2069540241 cites W2091100287 @default.
• W2069540241 cites W2093274070 @default.
• W2069540241 cites W2097146143 @default.
• W2069540241 cites W2098178319 @default.
• W2069540241 cites W2099486726 @default.
• W2069540241 cites W2100047947 @default.
• W2069540241 cites W2100067998 @default.
• W2069540241 cites W2101600063 @default.
• W2069540241 cites W2104359514 @default.
• W2069540241 cites W2110225855 @default.
• W2069540241 cites W2111757867 @default.
• W2069540241 cites W2120792160 @default.
• W2069540241 cites W2121303369 @default.
• W2069540241 cites W2122023734 @default.
• W2069540241 cites W2122932666 @default.
• W2069540241 cites W2124345456 @default.
• W2069540241 cites W2129411407 @default.
• W2069540241 cites W2130200374 @default.
• W2069540241 cites W2132641230 @default.
• W2069540241 cites W2133430418 @default.
• W2069540241 cites W2140373856 @default.
• W2069540241 cites W2140695384 @default.
• W2069540241 cites W2140725636 @default.
• W2069540241 cites W2141478497 @default.
• W2069540241 cites W2144175661 @default.
• W2069540241 cites W2144821195 @default.
• W2069540241 cites W2145189896 @default.
• W2069540241 cites W2147712103 @default.
• W2069540241 cites W2151061204 @default.
• W2069540241 cites W2151656896 @default.
• W2069540241 cites W2152573599 @default.
• W2069540241 cites W2160397887 @default.
• W2069540241 cites W2164824098 @default.
• W2069540241 cites W2166050484 @default.
• W2069540241 cites W2168451060 @default.

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