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- W2069541617 abstract "CD31 (PECAM-1) is a highly abundant cell surface glycoprotein expressed on hemopoietic and endothelial cells where it functions as a homophilic adhesion and signaling receptor. Since dimerization and appropriate glycosylation are important features in the regulation of cell surface interactions and signal transduction, we studied the pattern of glycosylation as well as the ability of CD31 to undergo dimerization, both in solution and when expressed on cell membranes. CD31 is heavily glycosylated, with an approximate carbohydrate content of 21%. Nineteen neutral and thirteen sialylated glycans were identified. Ultracentrifugation analysis showed that soluble recombinant CD31 exists in equilibrium between a monomer and a dimer with an approximate dissociation constant of 12.5 microM. Chemical cross-linking studies of both soluble and membrane-expressed CD31 confirmed that CD31 exists as a dimer. These studies suggest that, like E-cadherin, PECAM-dimerization is likely to play a role in CD31 adhesion and signaling." @default.
- W2069541617 created "2016-06-24" @default.
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- W2069541617 date "1999-08-01" @default.
- W2069541617 modified "2023-10-03" @default.
- W2069541617 title "CD31 (PECAM-1) Exists as a Dimer and Is Heavily N-Glycosylated" @default.
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- W2069541617 doi "https://doi.org/10.1006/bbrc.1999.1018" @default.
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