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- W2069542406 abstract "The mechanism of resistance of strain R of Cladosporium cucumerinum resistant to 6-azauracil (AzU), 6-azauridine (AzUR) and to 6-azauridinemonophosphate (AzUMP) has been studied. Conversion of AzU into AzUR proceeds in the wild strain N and the resistant strain N equally well. Both, strain N and strain R convert AzUR into AzUMP. However, the amount of AzUMP detected in the resistant strain was approximately, three times lower than in strain N. This may be due to a change in the enzyme uridine kinase. The poor ability to form AzUMP from AzUR resulted in a higher activity of the enzyme orotidine monophosphate decarboxylase (OMP-decarboxylase) in strain R in this way interfering less with the incorporation of orotic acid into RNA of strain R than in that of strain N. Results indicate a lower incorporation of AzU into RNA of strain R as compared with strain N. Strain R possesses a different mechanism of resistance for AzUR and for AzUMP. Resistance of strain R to AzUMP depends on the inability of AzUMP to reach in sufficient amounts the enzyme OMP-decarboxylase. This may be due to a decreased rate of permeability of the resistant strain to AzUMP or to breakdown of the compound before reaching the site of action." @default.
- W2069542406 created "2016-06-24" @default.
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- W2069542406 date "1971-03-01" @default.
- W2069542406 modified "2023-09-23" @default.
- W2069542406 title "Mechanism of resistance of Cladosporium cucumerinum against 6-azauracil and 6-azauridinemonophosphate" @default.
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- W2069542406 doi "https://doi.org/10.1016/0048-3575(71)90207-0" @default.
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