Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069565996> ?p ?o ?g. }
- W2069565996 endingPage "591" @default.
- W2069565996 startingPage "575" @default.
- W2069565996 abstract "Disruption to different components of the prefrontal cortex, basal ganglia, and hippocampal circuits leads to various psychiatric and neurological disorders including Parkinson’s disease (PD) and schizophrenia. Medications used to treat these disorders (such as levodopa, dopamine agonists, antipsychotics, among others) affect the prefrontal-striatal-hippocampal circuits in a complex fashion. We have built models of prefrontal-striatal and striatal-hippocampal interactions which simulate cognitive dysfunction in PD and schizophrenia. In these models, we argue that the basal ganglia is key for stimulus-response learning, the hippocampus for stimulus-stimulus representational learning, and the prefrontal cortex for stimulus selection during learning about multidimensional stimuli. In our models, PD is associated with reduced dopamine levels in the basal ganglia and prefrontal cortex. In contrast, the cognitive deficits in schizophrenia are associated primarily with hippocampal dysfunction, while the occurrence of negative symptoms is associated with frontostriatal deficits in a subset of patients. In this paper, we review our past models and provide new simulation results for both PD and schizophrenia. We also describe an extended model that includes simulation of the different functional role of D1 and D2 dopamine receptors in the basal ganglia and prefrontal cortex, a dissociation we argue is essential for understanding the non-uniform effects of levodopa, dopamine agonists, and antipsychotics on cognition. Motivated by clinical and physiological data, we discuss model limitations and challenges to be addressed in future models of these brain disorders." @default.
- W2069565996 created "2016-06-24" @default.
- W2069565996 creator A5026110190 @default.
- W2069565996 creator A5073735097 @default.
- W2069565996 date "2011-08-01" @default.
- W2069565996 modified "2023-10-18" @default.
- W2069565996 title "Computational cognitive models of prefrontal-striatal-hippocampal interactions in Parkinson’s disease and schizophrenia" @default.
- W2069565996 cites W1496608909 @default.
- W2069565996 cites W1524835549 @default.
- W2069565996 cites W1641126678 @default.
- W2069565996 cites W1964561629 @default.
- W2069565996 cites W1967464402 @default.
- W2069565996 cites W1973364745 @default.
- W2069565996 cites W1974203772 @default.
- W2069565996 cites W1974385176 @default.
- W2069565996 cites W1974960577 @default.
- W2069565996 cites W1976284302 @default.
- W2069565996 cites W1976833051 @default.
- W2069565996 cites W1979455727 @default.
- W2069565996 cites W1979908112 @default.
- W2069565996 cites W1980046851 @default.
- W2069565996 cites W1980528265 @default.
- W2069565996 cites W1980737345 @default.
- W2069565996 cites W1981199626 @default.
- W2069565996 cites W1983672782 @default.
- W2069565996 cites W1987074340 @default.
- W2069565996 cites W1989703984 @default.
- W2069565996 cites W1990068200 @default.
- W2069565996 cites W1990152867 @default.
- W2069565996 cites W1992170205 @default.
- W2069565996 cites W1993555245 @default.
- W2069565996 cites W1993646796 @default.
- W2069565996 cites W1995587364 @default.
- W2069565996 cites W1996103716 @default.
- W2069565996 cites W1998736700 @default.
- W2069565996 cites W2001682485 @default.
- W2069565996 cites W2005173683 @default.
- W2069565996 cites W2005200453 @default.
- W2069565996 cites W2005498978 @default.
- W2069565996 cites W2008380962 @default.
- W2069565996 cites W2009928698 @default.
- W2069565996 cites W2010129023 @default.
- W2069565996 cites W2010810583 @default.
- W2069565996 cites W2010945210 @default.
- W2069565996 cites W2011849432 @default.
- W2069565996 cites W201262253 @default.
- W2069565996 cites W2014150662 @default.
- W2069565996 cites W2014540773 @default.
- W2069565996 cites W2016955957 @default.
- W2069565996 cites W2017796162 @default.
- W2069565996 cites W2020408936 @default.
- W2069565996 cites W2021088559 @default.
- W2069565996 cites W2022932156 @default.
- W2069565996 cites W2027387120 @default.
- W2069565996 cites W2027465559 @default.
- W2069565996 cites W2028801244 @default.
- W2069565996 cites W2029915913 @default.
- W2069565996 cites W2032832443 @default.
- W2069565996 cites W2033080466 @default.
- W2069565996 cites W2036790475 @default.
- W2069565996 cites W2036892124 @default.
- W2069565996 cites W2040379380 @default.
- W2069565996 cites W2040886908 @default.
- W2069565996 cites W2044811488 @default.
- W2069565996 cites W2045696805 @default.
- W2069565996 cites W2047054629 @default.
- W2069565996 cites W2047057213 @default.
- W2069565996 cites W2047710557 @default.
- W2069565996 cites W2048396168 @default.
- W2069565996 cites W2051756412 @default.
- W2069565996 cites W2053350293 @default.
- W2069565996 cites W2054317071 @default.
- W2069565996 cites W2055523610 @default.
- W2069565996 cites W2057024097 @default.
- W2069565996 cites W2057641276 @default.
- W2069565996 cites W2058166202 @default.
- W2069565996 cites W2059389314 @default.
- W2069565996 cites W2060052647 @default.
- W2069565996 cites W2062484697 @default.
- W2069565996 cites W2063293639 @default.
- W2069565996 cites W2064900699 @default.
- W2069565996 cites W2065020698 @default.
- W2069565996 cites W2065931730 @default.
- W2069565996 cites W2066868744 @default.
- W2069565996 cites W2067232404 @default.
- W2069565996 cites W2068949971 @default.
- W2069565996 cites W2069223718 @default.
- W2069565996 cites W2071049015 @default.
- W2069565996 cites W2072406115 @default.
- W2069565996 cites W2073618643 @default.
- W2069565996 cites W2073782853 @default.
- W2069565996 cites W2074241729 @default.
- W2069565996 cites W2076660877 @default.
- W2069565996 cites W2076746996 @default.
- W2069565996 cites W2076784212 @default.
- W2069565996 cites W2077413974 @default.
- W2069565996 cites W2077767624 @default.
- W2069565996 cites W2078633164 @default.