FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069567047> ?p ?o ?g. }

• W2069567047 endingPage "899" @default.
• W2069567047 startingPage "889" @default.
• W2069567047 abstract "Cathepsin E is an intracellular, non-lysosomal aspartic protease expressed in a variety of cells and tissues. The protease has proposed physiological roles in antigen presentation by the MHC class II system, in the biogenesis of the vasoconstrictor peptide endothelin, and in neurodegeneration associated with brain ischemia and aging. Cathepsin E is the only A1 aspartic protease that exists as a homodimer with a disulfide bridge linking the two monomers. Like many other aspartic proteases, it is synthesized as a zymogen which is catalytically inactive towards its natural substrates at neutral pH and which auto-activates in an acidic environment. Here we report the crystal structure of an activation intermediate of human cathepsin E at 2.35A resolution. The overall structure follows the general fold of aspartic proteases of the A1 family, and the intermediate shares many features with the intermediate 2 on the proposed activation pathway of aspartic proteases like pepsin C and cathepsin D. The pro-sequence is cleaved from the protease and remains stably associated with the mature enzyme by forming the outermost sixth strand of the interdomain beta-sheet. However, different from these other aspartic proteases the pro-sequence of cathepsin E remains intact after cleavage from the mature enzyme. In addition, the active site of cathepsin E in the crystal is occupied by N-terminal amino acid residues of the mature protease in the non-primed binding site and by an artificial N-terminal extension of the pro-sequence from a neighboring molecule in the primed site. The crystal structure of the cathepsin E/pro-sequence complex, therefore, provides further insight into the activation mechanism of aspartic proteases." @default.
• W2069567047 created "2016-06-24" @default.
• W2069567047 creator A5030415981 @default.
• W2069567047 creator A5053133148 @default.
• W2069567047 creator A5067152609 @default.
• W2069567047 creator A5071619134 @default.
• W2069567047 creator A5081354349 @default.
• W2069567047 date "2004-09-01" @default.
• W2069567047 modified "2023-09-28" @default.
• W2069567047 title "Crystal Structure of an Activation Intermediate of Cathepsin E" @default.
• W2069567047 cites W1486197790 @default.
• W2069567047 cites W1529725823 @default.
• W2069567047 cites W1535473490 @default.
• W2069567047 cites W1562575254 @default.
• W2069567047 cites W1894490140 @default.
• W2069567047 cites W1967824198 @default.
• W2069567047 cites W1985469117 @default.
• W2069567047 cites W1986191025 @default.
• W2069567047 cites W1987452659 @default.
• W2069567047 cites W1992636402 @default.
• W2069567047 cites W1995017064 @default.
• W2069567047 cites W2001641653 @default.
• W2069567047 cites W2013083986 @default.
• W2069567047 cites W2024072727 @default.
• W2069567047 cites W2028231353 @default.
• W2069567047 cites W2031947881 @default.
• W2069567047 cites W2035148735 @default.
• W2069567047 cites W2047908011 @default.
• W2069567047 cites W2053999577 @default.
• W2069567047 cites W2054329337 @default.
• W2069567047 cites W2054846759 @default.
• W2069567047 cites W2058519081 @default.
• W2069567047 cites W2071958927 @default.
• W2069567047 cites W2078248419 @default.
• W2069567047 cites W2080800689 @default.
• W2069567047 cites W2084347696 @default.
• W2069567047 cites W2088228815 @default.
• W2069567047 cites W2090553671 @default.
• W2069567047 cites W2097493124 @default.
• W2069567047 cites W2109344094 @default.
• W2069567047 cites W2110515054 @default.
• W2069567047 cites W2116275717 @default.
• W2069567047 cites W2118173386 @default.
• W2069567047 cites W2133019124 @default.
• W2069567047 cites W2160648866 @default.
• W2069567047 cites W2164231548 @default.
• W2069567047 cites W2171316918 @default.
• W2069567047 cites W4256521422 @default.
• W2069567047 cites W4312514400 @default.
• W2069567047 doi "https://doi.org/10.1016/j.jmb.2004.07.073" @default.
• W2069567047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15342244" @default.
• W2069567047 hasPublicationYear "2004" @default.
• W2069567047 type Work @default.
• W2069567047 sameAs 2069567047 @default.
• W2069567047 citedByCount "28" @default.
• W2069567047 countsByYear W20695670472012 @default.
• W2069567047 countsByYear W20695670472013 @default.
• W2069567047 countsByYear W20695670472015 @default.
• W2069567047 countsByYear W20695670472016 @default.
• W2069567047 countsByYear W20695670472017 @default.
• W2069567047 countsByYear W20695670472018 @default.
• W2069567047 countsByYear W20695670472019 @default.
• W2069567047 countsByYear W20695670472020 @default.
• W2069567047 crossrefType "journal-article" @default.
• W2069567047 hasAuthorship W2069567047A5030415981 @default.
• W2069567047 hasAuthorship W2069567047A5053133148 @default.
• W2069567047 hasAuthorship W2069567047A5067152609 @default.
• W2069567047 hasAuthorship W2069567047A5071619134 @default.
• W2069567047 hasAuthorship W2069567047A5081354349 @default.
• W2069567047 hasConcept C104317684 @default.
• W2069567047 hasConcept C145734084 @default.
• W2069567047 hasConcept C151701858 @default.
• W2069567047 hasConcept C167625842 @default.
• W2069567047 hasConcept C167844969 @default.
• W2069567047 hasConcept C173633252 @default.
• W2069567047 hasConcept C174937957 @default.
• W2069567047 hasConcept C181199279 @default.
• W2069567047 hasConcept C182220744 @default.
• W2069567047 hasConcept C185592680 @default.
• W2069567047 hasConcept C2776714187 @default.
• W2069567047 hasConcept C2777807008 @default.
• W2069567047 hasConcept C2778775115 @default.
• W2069567047 hasConcept C2781208047 @default.
• W2069567047 hasConcept C34695024 @default.
• W2069567047 hasConcept C515207424 @default.
• W2069567047 hasConcept C51618164 @default.
• W2069567047 hasConcept C55493867 @default.
• W2069567047 hasConcept C78553746 @default.
• W2069567047 hasConcept C81216549 @default.
• W2069567047 hasConcept C86803240 @default.
• W2069567047 hasConceptScore W2069567047C104317684 @default.
• W2069567047 hasConceptScore W2069567047C145734084 @default.
• W2069567047 hasConceptScore W2069567047C151701858 @default.
• W2069567047 hasConceptScore W2069567047C167625842 @default.
• W2069567047 hasConceptScore W2069567047C167844969 @default.
• W2069567047 hasConceptScore W2069567047C173633252 @default.
• W2069567047 hasConceptScore W2069567047C174937957 @default.
• W2069567047 hasConceptScore W2069567047C181199279 @default.

• next