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- W2069572034 abstract "DNA anaphase bridges are a potential source of genome instability that may lead to chromosome breakage or nondisjunction during mitosis. Two classes of anaphase bridges can be distinguished: DAPI-positive chromatin bridges and DAPI-negative ultrafine DNA bridges (UFBs). Here, we establish budding yeast Saccharomyces cerevisiae and the avian DT40 cell line as model systems for studying DNA anaphase bridges and show that TopBP1/Dpb11 plays an evolutionarily conserved role in their metabolism. Together with the single-stranded DNA binding protein RPA, TopBP1/Dpb11 binds to UFBs, and depletion of TopBP1/Dpb11 led to an accumulation of chromatin bridges. Importantly, the NoCut checkpoint that delays progression from anaphase to abscission in yeast was activated by both UFBs and chromatin bridges independently of Dpb11, and disruption of the NoCut checkpoint in Dpb11-depleted cells led to genome instability. In conclusion, we propose that TopBP1/Dpb11 prevents accumulation of anaphase bridges via stimulation of the Mec1/ATR kinase and suppression of homologous recombination." @default.
- W2069572034 created "2016-06-24" @default.
- W2069572034 creator A5000722285 @default.
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- W2069572034 date "2013-12-30" @default.
- W2069572034 modified "2023-10-14" @default.
- W2069572034 title "TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability" @default.
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- W2069572034 doi "https://doi.org/10.1083/jcb.201305157" @default.
- W2069572034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3882784" @default.
- W2069572034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24379413" @default.
- W2069572034 hasPublicationYear "2013" @default.
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