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• W2069573044 endingPage "1204" @default.
• W2069573044 startingPage "1192" @default.
• W2069573044 abstract "The tonotopic map of the mammalian cochlea is commonly thought to be determined by the passive mechanical properties of the basilar membrane. The other tissues and cells that make up the organ of Corti also have passive mechanical properties; however, their roles are less well understood. In addition, active forces produced by outer hair cells (OHCs) enhance the vibration of the basilar membrane, termed cochlear amplification. Here, we studied how these biomechanical components interact using optical coherence tomography, which permits vibratory measurements within tissue. We measured not only classical basilar membrane tuning curves, but also vibratory responses from the rest of the organ of Corti within the mouse cochlear apex in vivo. As expected, basilar membrane tuning was sharp in live mice and broad in dead mice. Interestingly, the vibratory response of the region lateral to the OHCs, the “lateral compartment,” demonstrated frequency-dependent phase differences relative to the basilar membrane. This was sharply tuned in both live and dead mice. We then measured basilar membrane and lateral compartment vibration in transgenic mice with targeted alterations in cochlear mechanics. Prestin 499/499 , Prestin −/− , and Tecta C1509G/C1509G mice demonstrated no cochlear amplification but maintained the lateral compartment phase difference. In contrast, Sfswap Tg/Tg mice maintained cochlear amplification but did not demonstrate the lateral compartment phase difference. These data indicate that the organ of Corti has complex micromechanical vibratory characteristics, with passive, yet sharply tuned, vibratory characteristics associated with the supporting cells. These characteristics may tune OHC force generation to produce the sharp frequency selectivity of mammalian hearing." @default.
• W2069573044 created "2016-06-24" @default.
• W2069573044 creator A5028537926 @default.
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• W2069573044 date "2014-09-01" @default.
• W2069573044 modified "2023-10-13" @default.
• W2069573044 title "Vibration of the organ of Corti within the cochlear apex in mice" @default.
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• W2069573044 doi "https://doi.org/10.1152/jn.00306.2014" @default.
• W2069573044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4122729" @default.
• W2069573044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24920025" @default.
• W2069573044 hasPublicationYear "2014" @default.
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