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- W2069573119 abstract "We studied a pharmacologic approach using a potent peptidyl antiproliferative agent, angiopeptin, to prevent the myointimal hyperplasia that occurs as a diseased vessel is replaced with an artificial graft or treated by an intravascular device. In vitro cell culture studies showed that the proliferative potential of smooth muscle cells was dose dependently reduced, whereas the migratory response was reduced to a lesser degree. In a well defined injured rat artery model, in which a denuded aorta was prepared by collagenase treatment, followed by isotransplantation, a remarkable suppressive effect of angiopeptin on myointimal hyperplasia was observed with daily subcutaneous injection. Local sustained release from a biodegradable polymeric gel coated on an injured vessel was also effective in the prevention of myointimal hyperplasia. Slightly retarded endothelial regeneration was noticed. The potential application to small caliber artificial grafts is discussed." @default.
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- W2069573119 date "1993-07-01" @default.
- W2069573119 modified "2023-09-27" @default.
- W2069573119 title "Angiopeptin as a Potent Inhibitor of Myointimal Hyperplasia" @default.
- W2069573119 doi "https://doi.org/10.1097/00002480-199307000-00072" @default.
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