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• W2069593751 abstract "In the present study, we examined whether anti-CD40+IL-4-mediated B cell proliferation and immunoglobulin synthesis is affected by vitamin D (VD) and its low-hypercalcemic analogue EB1089 in Bcells from healthy donors. Analysis of vitamin D receptor (VDR) expression showed that only anti-CD40+IL-4-stimulated, but not resting B cells express VDR. Studies on B cell proliferation revealed that anti-CD40+IL-4-mediated proliferation of B cells was not affected by VD or EB1089. By contrast, IgE synthesis was markedly inhibited by both, VD and EB1089, starting at concentrations from 10–10 M for VD and 10–12 M for EB1089, with maximal inhibition at 10–6 M (VD 85.5±9.7%; EB1089 77.3±10.8%). The production of the other Ig (IgA and IgG) was not significantly inhibited by VD after anti-CD40+IL-4 stimulation, and IgM production was only slightly reduced (18.7±7.9%). These observations were confirmed by intracellular staining of the different isotypes in B cells after anti-CD40+IL-4 stimulation, which showed a strong reduction of IgE+ cells in the presence of VD. Analyses of molecules that are known to affect IgE production (CD23 and IL-6) revealed that these are not involved in VD-dependent inhibition of IgE production. By contrast, epsilon germ-line transcription was inhibited by VD (41.2±26.1%; n=5), as was NF-κB (p50 and p65) protein expression in stimulated cells. These data show that VD and its analogue EB1089 inhibit IgE production of anti-CD40+IL-4-stimulated B cells in vitro. Theinvolved mechanism includes epsilon germ-line transcription, NF-κB activation and switch recombination suggesting that complex mechanisms of VD action in anti-CD40+IL-4-stimulated B cells areresponsible." @default.
• W2069593751 created "2016-06-24" @default.
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• W2069593751 date "2002-11-13" @default.
• W2069593751 modified "2023-10-13" @default.
• W2069593751 title "1α,25‐dihydroxyvitamin D₃inhibits anti‐CD40 plus IL‐4‐mediated IgE production<i>in vitro</i>" @default.
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• W2069593751 doi "https://doi.org/10.1002/1521-4141(200212)32:12<3395::aid-immu3395>3.0.co;2-#" @default.
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