Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069594369> ?p ?o ?g. }
- W2069594369 endingPage "998" @default.
- W2069594369 startingPage "991" @default.
- W2069594369 abstract "Peroxisome proliferator-activated receptors, PPARα, PPARβ/δ and PPARγ, are fatty acid activated transcription factors that belong to the nuclear hormone receptor family. While they are best known as transcriptional regulators of lipid and glucose metabolism, evidence has also accumulated for their importance in skin homeostasis. The three PPAR isotypes are expressed in rodent and human skin. Various cell culture and in vivo approaches suggest that PPARα contributes to fetal skin development, to epidermal barrier maturation and to sebocyte activity. PPARβ/δ regulates sebocyte differentiation, promotes hair follicle growth and has pro-differentiating effects in keratinocytes in normal and inflammatory conditions. In contrast, the role of PPARγ appears to be rather minor in keratinocytes, whereas its activity is required for sebaceous gland differentiation. Importantly, PPARα and β/δ are instrumental in skin repair after an injury, each of them playing specific roles. Due to their collective diverse functions in skin biology, PPARs represent a major research target for the understanding and treatment of many skin diseases, such as benign epidermal tumors, papillomas, acne vulgaris and psoriasis." @default.
- W2069594369 created "2016-06-24" @default.
- W2069594369 creator A5005016908 @default.
- W2069594369 creator A5078475681 @default.
- W2069594369 date "2007-08-01" @default.
- W2069594369 modified "2023-10-06" @default.
- W2069594369 title "Peroxisome proliferator-activated receptors (PPARs) in skin health, repair and disease" @default.
- W2069594369 cites W1486904951 @default.
- W2069594369 cites W1487581481 @default.
- W2069594369 cites W1548818703 @default.
- W2069594369 cites W1593435794 @default.
- W2069594369 cites W1855629754 @default.
- W2069594369 cites W1964795669 @default.
- W2069594369 cites W1968703258 @default.
- W2069594369 cites W1978267311 @default.
- W2069594369 cites W1978440962 @default.
- W2069594369 cites W1978501266 @default.
- W2069594369 cites W1984903500 @default.
- W2069594369 cites W1987447521 @default.
- W2069594369 cites W1988967018 @default.
- W2069594369 cites W1989002053 @default.
- W2069594369 cites W1991215819 @default.
- W2069594369 cites W1994570427 @default.
- W2069594369 cites W1996462669 @default.
- W2069594369 cites W1999307521 @default.
- W2069594369 cites W2000288816 @default.
- W2069594369 cites W2000590402 @default.
- W2069594369 cites W2003311380 @default.
- W2069594369 cites W2003525762 @default.
- W2069594369 cites W2004501846 @default.
- W2069594369 cites W2006784168 @default.
- W2069594369 cites W2015366764 @default.
- W2069594369 cites W2017056299 @default.
- W2069594369 cites W2024497383 @default.
- W2069594369 cites W2029653522 @default.
- W2069594369 cites W2032918258 @default.
- W2069594369 cites W2037483364 @default.
- W2069594369 cites W2039663743 @default.
- W2069594369 cites W2042204452 @default.
- W2069594369 cites W2042308845 @default.
- W2069594369 cites W2054154194 @default.
- W2069594369 cites W2059966251 @default.
- W2069594369 cites W2062626453 @default.
- W2069594369 cites W2062899886 @default.
- W2069594369 cites W2067604610 @default.
- W2069594369 cites W2072353008 @default.
- W2069594369 cites W2074781403 @default.
- W2069594369 cites W2078643477 @default.
- W2069594369 cites W2082492482 @default.
- W2069594369 cites W2091673549 @default.
- W2069594369 cites W2092961460 @default.
- W2069594369 cites W2093221417 @default.
- W2069594369 cites W2093329656 @default.
- W2069594369 cites W2093351574 @default.
- W2069594369 cites W2094795797 @default.
- W2069594369 cites W2105078414 @default.
- W2069594369 cites W2110722372 @default.
- W2069594369 cites W2112761401 @default.
- W2069594369 cites W2118820170 @default.
- W2069594369 cites W2119448646 @default.
- W2069594369 cites W2121617717 @default.
- W2069594369 cites W2121790141 @default.
- W2069594369 cites W2121914083 @default.
- W2069594369 cites W2128887954 @default.
- W2069594369 cites W2131471654 @default.
- W2069594369 cites W2132741387 @default.
- W2069594369 cites W2136466565 @default.
- W2069594369 cites W2141178367 @default.
- W2069594369 cites W2142239045 @default.
- W2069594369 cites W2149182758 @default.
- W2069594369 cites W2149287982 @default.
- W2069594369 cites W2154476890 @default.
- W2069594369 cites W2157639204 @default.
- W2069594369 cites W2165128851 @default.
- W2069594369 cites W2166796677 @default.
- W2069594369 cites W2195166311 @default.
- W2069594369 cites W2605614532 @default.
- W2069594369 doi "https://doi.org/10.1016/j.bbalip.2007.02.004" @default.
- W2069594369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17400022" @default.
- W2069594369 hasPublicationYear "2007" @default.
- W2069594369 type Work @default.
- W2069594369 sameAs 2069594369 @default.
- W2069594369 citedByCount "161" @default.
- W2069594369 countsByYear W20695943692012 @default.
- W2069594369 countsByYear W20695943692013 @default.
- W2069594369 countsByYear W20695943692014 @default.
- W2069594369 countsByYear W20695943692015 @default.
- W2069594369 countsByYear W20695943692016 @default.
- W2069594369 countsByYear W20695943692017 @default.
- W2069594369 countsByYear W20695943692018 @default.
- W2069594369 countsByYear W20695943692019 @default.
- W2069594369 countsByYear W20695943692020 @default.
- W2069594369 countsByYear W20695943692021 @default.
- W2069594369 countsByYear W20695943692022 @default.
- W2069594369 countsByYear W20695943692023 @default.
- W2069594369 crossrefType "journal-article" @default.
- W2069594369 hasAuthorship W2069594369A5005016908 @default.
- W2069594369 hasAuthorship W2069594369A5078475681 @default.