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- W2069595989 abstract "Perinatal transmission of HBV occurs only in a minority of cases in HbeAg-negative women, more frequent associated with self-limited infection or fulminant hepatitis. The pathogenic mechanisms leading to the different clinical patterns and duration of hepatitis have not yet been completely clarified. Therefore, the descriptions of single cases may add some useful information. A 12-year-old girl diagnosed a chronic HBeAg-positive, HBV hepatitis, after two 6-month courses of IFN seroconverted to anti-HBe, cleared active viral replication, normalized ALT, maintaining the profile of an inactive HBV carrier. In the same virological condition, at the age of 21 years, she gave birth to a couple of non-identical twins. Although both the infants underwent complete immunoprofilaxis at birth, one of them at the age of 3 years was occasionally found to have ALT fourfold the norm. She was HBsAg, anti-HBe positive with an HBV viremia of 4020000 IU/ml (PCR upper limit 60 IU/ml). A complete virologic characterization performed by direct sequencing of the s and c region demonstrated that she was infected by a D HBV genotype, the only mutation (>90% of viral population) being a G to A switch at 1896 nt in the BCP/pre-core region. The viremia spontaneously reduced to 170 IU/ml and ALT normalized over the two following years. Her sister too resulted actively immunized being anti-HBs, anti-core positive." @default.
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- W2069595989 date "2007-10-01" @default.
- W2069595989 modified "2023-09-27" @default.
- W2069595989 title "Predominant pre-core mutation hastens an early control of HBV replication with transition to the inactive carrier status in HBV vertically infected children" @default.
- W2069595989 doi "https://doi.org/10.1016/j.dld.2007.07.146" @default.
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