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- W2069600959 abstract "Abstract The aminonucleoside of puromycin will inhibit RNA synthesis in cultured hamster embryo cells with little effect on protein synthesis for several hours. In other systems, the drug-induced inhibition of RNA synthesis has been interpreted as a specific inhibition of ribosomal RNA (rRNA) synthesis with only a small effect on messenger RNA (mRNA) synthesis. In contrast, no evidence was found in this system for such a selective inhibition, as the synthesis of rRNA, ‘heavy nuclear’ RNA, and polysomal mRNA were all inhibited to approximately equal extent by the drug. In addition, the results are consistent with the interpretation that rRNA synthesized in the presence of the drug is open to more than normal degradation during its maturation and incorporation into ribosomes." @default.
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- W2069600959 date "1968-02-01" @default.
- W2069600959 modified "2023-10-14" @default.
- W2069600959 title "The synthesis of RNA by mammalian cells treated with the aminonucleoside of puromycin" @default.
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- W2069600959 doi "https://doi.org/10.1016/0005-2787(68)90187-1" @default.
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