FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069616912> ?p ?o ?g. }

• W2069616912 endingPage "16167" @default.
• W2069616912 startingPage "16158" @default.
• W2069616912 abstract "Lysine acetylation is a major post-translational modification of proteins and regulates many physiological processes such as metabolism, cell migration, aging, and inflammation. Proteomic studies have identified numerous lysine-acetylated proteins in human and mouse models (Kim, S. C., Sprung, R., Chen, Y., Xu, Y., Ball, H., Pei, J., Cheng, T., Kho, Y., Xiao, H., Xiao, L., Grishin, N. V., White, M., Yang, X. J., and Zhao, Y. (2006) Mol. Cell 23, 607-618). One family of proteins identified in this study was the murine glycine N-acyltransferase (GLYAT) enzymes, which are acetylated on lysine 19. Lysine 19 is a conserved residue in human glycine N-acyltransferase-like 2 (hGLYATL2) and in several other species, showing that this residue may be important for enzyme function. Mutation of lysine 19 in recombinant hGLYATL2 to glutamine (K19Q) and arginine (K19R) resulted in a 50-80% lower production of N-oleoyl glycine and N-arachidonoylglycine, indicating that lysine 19 is important for enzyme function. LC/MS/MS confirmed that Lys-19 is not acetylated in wild-type hGLYATL2, indicating that Lys-19 requires to be deacetylated for full activity. The hGLYATL2 enzyme conjugates medium- and long-chain saturated and unsaturated acyl-CoA esters to glycine, resulting in the production of N-oleoyl glycine and also N-arachidonoyl glycine. N-Oleoyl glycine and N-arachidonoyl glycine are structurally and functionally related to endocannabinoids and have been identified as signaling molecules that regulate functions like the perception of pain and body temperature and also have anti-inflammatory properties. In conclusion, acetylation of lysine(s) in hGLYATL2 regulates the enzyme activity, thus linking post-translational modification of proteins with the production of biological signaling molecules, the N-acyl glycines." @default.
• W2069616912 created "2016-06-24" @default.
• W2069616912 creator A5000590565 @default.
• W2069616912 creator A5005267830 @default.
• W2069616912 creator A5039025880 @default.
• W2069616912 creator A5041131837 @default.
• W2069616912 creator A5091584856 @default.
• W2069616912 date "2012-05-01" @default.
• W2069616912 modified "2023-10-16" @default.
• W2069616912 title "Reversible Lysine Acetylation Regulates Activity of Human Glycine N-Acyltransferase-like 2 (hGLYATL2)" @default.
• W2069616912 cites W126864726 @default.
• W2069616912 cites W157425433 @default.
• W2069616912 cites W1604739454 @default.
• W2069616912 cites W196082105 @default.
• W2069616912 cites W1966821405 @default.
• W2069616912 cites W1970629672 @default.
• W2069616912 cites W1976768202 @default.
• W2069616912 cites W1998499089 @default.
• W2069616912 cites W2005789183 @default.
• W2069616912 cites W2010764626 @default.
• W2069616912 cites W2028161249 @default.
• W2069616912 cites W2029130907 @default.
• W2069616912 cites W2030637684 @default.
• W2069616912 cites W2034614265 @default.
• W2069616912 cites W2035705084 @default.
• W2069616912 cites W2042544913 @default.
• W2069616912 cites W2044609482 @default.
• W2069616912 cites W2048314147 @default.
• W2069616912 cites W2060510261 @default.
• W2069616912 cites W2066375788 @default.
• W2069616912 cites W2071438553 @default.
• W2069616912 cites W2071877843 @default.
• W2069616912 cites W2075430530 @default.
• W2069616912 cites W2075747312 @default.
• W2069616912 cites W2083970703 @default.
• W2069616912 cites W2087019732 @default.
• W2069616912 cites W2087714970 @default.
• W2069616912 cites W2090381051 @default.
• W2069616912 cites W2100028870 @default.
• W2069616912 cites W2101979121 @default.
• W2069616912 cites W2106715610 @default.
• W2069616912 cites W2107421255 @default.
• W2069616912 cites W2119097555 @default.
• W2069616912 cites W2119766530 @default.
• W2069616912 cites W2138357748 @default.
• W2069616912 cites W2147842931 @default.
• W2069616912 doi "https://doi.org/10.1074/jbc.m112.347260" @default.
• W2069616912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3351282" @default.
• W2069616912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22408254" @default.
• W2069616912 hasPublicationYear "2012" @default.
• W2069616912 type Work @default.
• W2069616912 sameAs 2069616912 @default.
• W2069616912 citedByCount "15" @default.
• W2069616912 countsByYear W20696169122013 @default.
• W2069616912 countsByYear W20696169122014 @default.
• W2069616912 countsByYear W20696169122015 @default.
• W2069616912 countsByYear W20696169122016 @default.
• W2069616912 countsByYear W20696169122017 @default.
• W2069616912 countsByYear W20696169122019 @default.
• W2069616912 countsByYear W20696169122020 @default.
• W2069616912 countsByYear W20696169122021 @default.
• W2069616912 crossrefType "journal-article" @default.
• W2069616912 hasAuthorship W2069616912A5000590565 @default.
• W2069616912 hasAuthorship W2069616912A5005267830 @default.
• W2069616912 hasAuthorship W2069616912A5039025880 @default.
• W2069616912 hasAuthorship W2069616912A5041131837 @default.
• W2069616912 hasAuthorship W2069616912A5091584856 @default.
• W2069616912 hasBestOaLocation W20696169121 @default.
• W2069616912 hasConcept C104317684 @default.
• W2069616912 hasConcept C119157956 @default.
• W2069616912 hasConcept C181199279 @default.
• W2069616912 hasConcept C185592680 @default.
• W2069616912 hasConcept C2775970874 @default.
• W2069616912 hasConcept C2776016237 @default.
• W2069616912 hasConcept C2777468819 @default.
• W2069616912 hasConcept C2777756961 @default.
• W2069616912 hasConcept C515207424 @default.
• W2069616912 hasConcept C55493867 @default.
• W2069616912 hasConcept C86803240 @default.
• W2069616912 hasConceptScore W2069616912C104317684 @default.
• W2069616912 hasConceptScore W2069616912C119157956 @default.
• W2069616912 hasConceptScore W2069616912C181199279 @default.
• W2069616912 hasConceptScore W2069616912C185592680 @default.
• W2069616912 hasConceptScore W2069616912C2775970874 @default.
• W2069616912 hasConceptScore W2069616912C2776016237 @default.
• W2069616912 hasConceptScore W2069616912C2777468819 @default.
• W2069616912 hasConceptScore W2069616912C2777756961 @default.
• W2069616912 hasConceptScore W2069616912C515207424 @default.
• W2069616912 hasConceptScore W2069616912C55493867 @default.
• W2069616912 hasConceptScore W2069616912C86803240 @default.
• W2069616912 hasIssue "20" @default.
• W2069616912 hasLocation W20696169121 @default.
• W2069616912 hasLocation W20696169122 @default.
• W2069616912 hasLocation W20696169123 @default.
• W2069616912 hasLocation W20696169124 @default.
• W2069616912 hasOpenAccess W2069616912 @default.
• W2069616912 hasPrimaryLocation W20696169121 @default.
• W2069616912 hasRelatedWork W1899984547 @default.

• next