FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069631424> ?p ?o ?g. }

• W2069631424 endingPage "2056" @default.
• W2069631424 startingPage "2051" @default.
• W2069631424 abstract "Objectives— An inflammatory response to altered lipoproteins that accumulate in the arterial wall is a major component of the pathogenesis of atherosclerosis. Statins reduce plasma levels of low-density lipoprotein (LDL) and are effective treatments for atherosclerosis. It is hypothesized that they also modulate inflammation. The aim of this study was to examine whether lovastatin inhibits macrophage inflammatory processes and clarify its mechanism of action. Methods and Results— We examined the effects of statins on phagocytosis of antibody-coated red blood cells by cultured human monocytes and mouse peritoneal macrophages. Lovastatin, simvastatin, and zaragozic acid, a squalene synthase inhibitor, blocked Fc receptor–mediated phagocytosis by cultured human monocytes and mouse peritoneal macrophages. The inhibitory effect of lovastatin on Fc receptor–mediated phagocytosis was prevented completely by addition of mevalonate, farnesyl pyrophosphate, LDL, or cholesterol to the culture medium. The inhibitory effect of zaragozic acid was reversed by addition of LDL, but not by the addition of geranylgeranyl pyrophosphate, to the medium. In addition, the effect of lovastatin on phagocytosis is a function of cell activation because treatment of cells with tumor necrosis factor-α or lipopolysaccharide prevented inhibition of phagocytosis by lovastatin. Conclusions— The inhibition of Fc receptor–mediated phagocytosis of lovastatin is related to its effect on cholesterol biosynthesis rather than its effect on the formation of isoprenoids." @default.
• W2069631424 created "2016-06-24" @default.
• W2069631424 creator A5014636384 @default.
• W2069631424 creator A5020507909 @default.
• W2069631424 creator A5027892366 @default.
• W2069631424 creator A5030604061 @default.
• W2069631424 creator A5053163315 @default.
• W2069631424 creator A5066507748 @default.
• W2069631424 creator A5069978424 @default.
• W2069631424 creator A5091831686 @default.
• W2069631424 date "2004-11-01" @default.
• W2069631424 modified "2023-10-06" @default.
• W2069631424 title "Statin Inhibition of Fc Receptor–Mediated Phagocytosis by Macrophages Is Modulated by Cell Activation and Cholesterol" @default.
• W2069631424 cites W1479880028 @default.
• W2069631424 cites W1611640819 @default.
• W2069631424 cites W1951754674 @default.
• W2069631424 cites W1969277178 @default.
• W2069631424 cites W1973234124 @default.
• W2069631424 cites W1979483374 @default.
• W2069631424 cites W1991469067 @default.
• W2069631424 cites W1993904515 @default.
• W2069631424 cites W1997411618 @default.
• W2069631424 cites W2030990272 @default.
• W2069631424 cites W2032519125 @default.
• W2069631424 cites W2044806074 @default.
• W2069631424 cites W2045279426 @default.
• W2069631424 cites W2053669774 @default.
• W2069631424 cites W2074090170 @default.
• W2069631424 cites W2080296240 @default.
• W2069631424 cites W2098183236 @default.
• W2069631424 cites W2109063792 @default.
• W2069631424 cites W2111694200 @default.
• W2069631424 cites W2121037015 @default.
• W2069631424 cites W2126708809 @default.
• W2069631424 cites W2129486859 @default.
• W2069631424 cites W2132600744 @default.
• W2069631424 cites W2138432239 @default.
• W2069631424 cites W2144058754 @default.
• W2069631424 cites W2151902098 @default.
• W2069631424 cites W2155444616 @default.
• W2069631424 cites W2162770644 @default.
• W2069631424 cites W2167454162 @default.
• W2069631424 cites W2180956139 @default.
• W2069631424 cites W2316243284 @default.
• W2069631424 cites W2419904856 @default.
• W2069631424 doi "https://doi.org/10.1161/01.atv.0000143858.15909.29" @default.
• W2069631424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15345508" @default.
• W2069631424 hasPublicationYear "2004" @default.
• W2069631424 type Work @default.
• W2069631424 sameAs 2069631424 @default.
• W2069631424 citedByCount "65" @default.
• W2069631424 countsByYear W20696314242012 @default.
• W2069631424 countsByYear W20696314242013 @default.
• W2069631424 countsByYear W20696314242014 @default.
• W2069631424 countsByYear W20696314242015 @default.
• W2069631424 countsByYear W20696314242016 @default.
• W2069631424 countsByYear W20696314242017 @default.
• W2069631424 countsByYear W20696314242018 @default.
• W2069631424 countsByYear W20696314242019 @default.
• W2069631424 countsByYear W20696314242020 @default.
• W2069631424 countsByYear W20696314242021 @default.
• W2069631424 countsByYear W20696314242022 @default.
• W2069631424 countsByYear W20696314242023 @default.
• W2069631424 crossrefType "journal-article" @default.
• W2069631424 hasAuthorship W2069631424A5014636384 @default.
• W2069631424 hasAuthorship W2069631424A5020507909 @default.
• W2069631424 hasAuthorship W2069631424A5027892366 @default.
• W2069631424 hasAuthorship W2069631424A5030604061 @default.
• W2069631424 hasAuthorship W2069631424A5053163315 @default.
• W2069631424 hasAuthorship W2069631424A5066507748 @default.
• W2069631424 hasAuthorship W2069631424A5069978424 @default.
• W2069631424 hasAuthorship W2069631424A5091831686 @default.
• W2069631424 hasBestOaLocation W20696314241 @default.
• W2069631424 hasConcept C160448771 @default.
• W2069631424 hasConcept C170493617 @default.
• W2069631424 hasConcept C181199279 @default.
• W2069631424 hasConcept C185592680 @default.
• W2069631424 hasConcept C202751555 @default.
• W2069631424 hasConcept C203014093 @default.
• W2069631424 hasConcept C2776120743 @default.
• W2069631424 hasConcept C2776914184 @default.
• W2069631424 hasConcept C2778163477 @default.
• W2069631424 hasConcept C2778754761 @default.
• W2069631424 hasConcept C2779244956 @default.
• W2069631424 hasConcept C2779519902 @default.
• W2069631424 hasConcept C2779982574 @default.
• W2069631424 hasConcept C2780940807 @default.
• W2069631424 hasConcept C553450214 @default.
• W2069631424 hasConcept C55493867 @default.
• W2069631424 hasConcept C86803240 @default.
• W2069631424 hasConcept C98274493 @default.
• W2069631424 hasConceptScore W2069631424C160448771 @default.
• W2069631424 hasConceptScore W2069631424C170493617 @default.
• W2069631424 hasConceptScore W2069631424C181199279 @default.
• W2069631424 hasConceptScore W2069631424C185592680 @default.
• W2069631424 hasConceptScore W2069631424C202751555 @default.
• W2069631424 hasConceptScore W2069631424C203014093 @default.
• W2069631424 hasConceptScore W2069631424C2776120743 @default.

• next