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• W2069651570 startingPage "172" @default.
• W2069651570 abstract "Abstract Cleavage of the HA polypeptide, the largest glycoprotein of the WSN strain of influenza virus, to polypeptides HA1 plus HA2 occurs when influenza virus is grown in MDBK cells in medium containing 2% calf serum, but does not occur in serum-free medium. Addition of highly purified plasminogen in concentrations as low as 1.5 μg/ml to serum-free medium results in complete cleavage. The release of plasminogen activators by the cell is essential for the activation of the zymogen and cleavage of the HA polypeptide. Either chick or calf plasminogen can be converted to the active enzyme, plasmin, by activators produced by either infected or uninfected MDBK cells. Cleavage of the HA polypeptide by plasmin can be prevented by trypsin inhibitors from bovine pancreas (Kunitz) or soybean. Cleavage does not occur in the presence of 2% calf serum from which plasminogen has been removed specifically by affinity chromatography, indicating that plasminogen is the only serum component involved in the conversion of the HA polypeptide to HA1 plus HA2. The results obtained indicate that in the MDBK cell-WSN strain system, cleavage of the HA polypeptide can be explained by the activation of serum plasminogen by cellular activators, and that cleavage of the influenza virus hemagglutinin polypeptide is a sensitive indicator of the production of plasminogen activators by cells." @default.
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• W2069651570 date "1973-11-01" @default.
• W2069651570 modified "2023-10-17" @default.
• W2069651570 title "Proteolytic cleavage by plasmin of the HA polypeptide of influenza virus: Host cell activation of serum plasminogen" @default.
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• W2069651570 doi "https://doi.org/10.1016/0042-6822(73)90296-1" @default.
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