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• W2069654297 abstract "To assess the extent to which interleukin-1β (IL-1β) may contribute to the development and/or progression of neurodegenerative processes, we have examined the levels of IL-1β in the brain of two types of neurological mutant mice, staggerer and Lurcher. Using a quantitative immunological method (enzyme-linked immunosorbent assay, ELISA), we measured IL-1β in the cerebellum, hippocampus and cerebral cortex of mutant mice at baseline and after peripheral LPS treatment. Two types of IL-1β expression abnormalities were found in the mutant cerebella: higher basal level in Lurcher and a response to peripheral administration of LPS in staggerer. The association of IL-1β expression abnormalities with the only brain structure where a massive neurodegeneration occurs supports the role of proinflammatory cytokines in this process." @default.
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• W2069654297 date "1998-11-01" @default.
• W2069654297 modified "2023-10-11" @default.
• W2069654297 title "Abnormal IL-1β cytokine expression in the cerebellum of the ataxic mutant mice staggerer and Lurcher" @default.
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• W2069654297 doi "https://doi.org/10.1016/s0169-328x(98)00268-x" @default.
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