FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069667003> ?p ?o ?g. }

• W2069667003 endingPage "49" @default.
• W2069667003 startingPage "42" @default.
• W2069667003 abstract "The Snake Venom Metalloproteinases (SVMPs) play a relevant role in the multifactorial inflammatory response induced by Bothrops envenomations. Neuwiedase, an SVMP isolated from Bothrops neuwiedi venom, is devoid of hemorrhagic activity on skin tests, but is able to induce myonecrosis and degrade fibrinogen, fibrin, type I collagen, fibronectin and laminin. In this study, we analyzed the inflammatory reaction induced by neuwiedase in gastrocnemius muscle, with special focus on cytokines release. Our results showed clear evidence of inflammatory infiltrate in the gastrocnemius muscle and an increase of MMP-9, and the cytokines KC, IL-1β and IL-6 in the early periods after toxin injection. The cytokine release was also evaluated in inflammatory and muscular cell culture. Both murine peritoneal adherent cells (MPACs) and muscle cells (C2C12) released pro-inflammatory cytokines after stimulus with neuwiedase. MPACs showed increased production of KC, IL-1β and IL-6 in the cell culture supernatant while in C2C12, the predominant chemokine expressed was KC. These data reinforce the importance of SVMPs in the inflammatory response caused by envenomation and point out the role of muscle cells in this event by releasing pro-inflammatory mediators able to attract leukocytes to the muscle, thus starting and amplifying the setting of the inflammatory reaction." @default.
• W2069667003 created "2016-06-24" @default.
• W2069667003 creator A5006143614 @default.
• W2069667003 creator A5006381283 @default.
• W2069667003 creator A5009490224 @default.
• W2069667003 creator A5022274389 @default.
• W2069667003 creator A5029465310 @default.
• W2069667003 creator A5033093137 @default.
• W2069667003 creator A5034224230 @default.
• W2069667003 creator A5063740591 @default.
• W2069667003 creator A5065823245 @default.
• W2069667003 creator A5080523244 @default.
• W2069667003 creator A5083163601 @default.
• W2069667003 date "2009-07-01" @default.
• W2069667003 modified "2023-09-27" @default.
• W2069667003 title "Characterization of inflammatory reaction induced by neuwiedase, a P-I metalloproteinase isolated from Bothrops neuwiedi venom" @default.
• W2069667003 cites W137274086 @default.
• W2069667003 cites W14836545 @default.
• W2069667003 cites W1968876368 @default.
• W2069667003 cites W1976398949 @default.
• W2069667003 cites W1986203517 @default.
• W2069667003 cites W1989913422 @default.
• W2069667003 cites W1993774985 @default.
• W2069667003 cites W1994787439 @default.
• W2069667003 cites W1996996763 @default.
• W2069667003 cites W2005746041 @default.
• W2069667003 cites W2007163708 @default.
• W2069667003 cites W2012993900 @default.
• W2069667003 cites W2020175638 @default.
• W2069667003 cites W2029840653 @default.
• W2069667003 cites W2032673478 @default.
• W2069667003 cites W2051752915 @default.
• W2069667003 cites W2062784484 @default.
• W2069667003 cites W2066754426 @default.
• W2069667003 cites W2070407020 @default.
• W2069667003 cites W2078855182 @default.
• W2069667003 cites W2097931754 @default.
• W2069667003 cites W2116117473 @default.
• W2069667003 cites W2136792386 @default.
• W2069667003 cites W2154232005 @default.
• W2069667003 cites W2165244754 @default.
• W2069667003 cites W2167537804 @default.
• W2069667003 cites W2292535579 @default.
• W2069667003 cites W4237637504 @default.
• W2069667003 cites W4249156097 @default.
• W2069667003 cites W4293247451 @default.
• W2069667003 cites W4294352168 @default.
• W2069667003 doi "https://doi.org/10.1016/j.toxicon.2009.03.007" @default.
• W2069667003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19285999" @default.
• W2069667003 hasPublicationYear "2009" @default.
• W2069667003 type Work @default.
• W2069667003 sameAs 2069667003 @default.
• W2069667003 citedByCount "31" @default.
• W2069667003 countsByYear W20696670032012 @default.
• W2069667003 countsByYear W20696670032013 @default.
• W2069667003 countsByYear W20696670032014 @default.
• W2069667003 countsByYear W20696670032015 @default.
• W2069667003 countsByYear W20696670032016 @default.
• W2069667003 countsByYear W20696670032017 @default.
• W2069667003 countsByYear W20696670032019 @default.
• W2069667003 countsByYear W20696670032020 @default.
• W2069667003 countsByYear W20696670032022 @default.
• W2069667003 crossrefType "journal-article" @default.
• W2069667003 hasAuthorship W2069667003A5006143614 @default.
• W2069667003 hasAuthorship W2069667003A5006381283 @default.
• W2069667003 hasAuthorship W2069667003A5009490224 @default.
• W2069667003 hasAuthorship W2069667003A5022274389 @default.
• W2069667003 hasAuthorship W2069667003A5029465310 @default.
• W2069667003 hasAuthorship W2069667003A5033093137 @default.
• W2069667003 hasAuthorship W2069667003A5034224230 @default.
• W2069667003 hasAuthorship W2069667003A5063740591 @default.
• W2069667003 hasAuthorship W2069667003A5065823245 @default.
• W2069667003 hasAuthorship W2069667003A5080523244 @default.
• W2069667003 hasAuthorship W2069667003A5083163601 @default.
• W2069667003 hasBestOaLocation W20696670031 @default.
• W2069667003 hasConcept C13373296 @default.
• W2069667003 hasConcept C145600735 @default.
• W2069667003 hasConcept C185592680 @default.
• W2069667003 hasConcept C203014093 @default.
• W2069667003 hasConcept C2776725428 @default.
• W2069667003 hasConcept C2776914184 @default.
• W2069667003 hasConcept C2779448229 @default.
• W2069667003 hasConcept C2779815518 @default.
• W2069667003 hasConcept C55493867 @default.
• W2069667003 hasConcept C86803240 @default.
• W2069667003 hasConceptScore W2069667003C13373296 @default.
• W2069667003 hasConceptScore W2069667003C145600735 @default.
• W2069667003 hasConceptScore W2069667003C185592680 @default.
• W2069667003 hasConceptScore W2069667003C203014093 @default.
• W2069667003 hasConceptScore W2069667003C2776725428 @default.
• W2069667003 hasConceptScore W2069667003C2776914184 @default.
• W2069667003 hasConceptScore W2069667003C2779448229 @default.
• W2069667003 hasConceptScore W2069667003C2779815518 @default.
• W2069667003 hasConceptScore W2069667003C55493867 @default.
• W2069667003 hasConceptScore W2069667003C86803240 @default.
• W2069667003 hasIssue "1" @default.
• W2069667003 hasLocation W20696670031 @default.
• W2069667003 hasLocation W20696670032 @default.

• next