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• W2069685280 abstract "Specialized membrane domains containing lipid rafts are thought to be important for membrane processes such as signaling and trafficking [1Mukherjee S. Maxfield F.R. Membrane domains.Annu. Rev. Cell Dev. Biol. 2004; 20: 839-866Crossref PubMed Scopus (325) Google Scholar, 2Rajendran L. Simons K. Lipid rafts and membrane dynamics.J. Cell Sci. 2005; 118: 1099-1102Crossref PubMed Scopus (450) Google Scholar]. An unconventional type I myosin has been shown to reside in lipid rafts and function to target a disaccharidase to rafts in brush borders of intestinal mammalian cells [3Tyska M.J. Mooseker M.S. A role for myosin-1A in the localization of a brush border disaccharidase.J. Cell Biol. 2004; 165: 395-405Crossref PubMed Scopus (64) Google Scholar]. In the fission yeast Schizosaccharomyces pombe, distinct sterol-rich membrane domains are formed at the cell division site and sites of polarized cell growth at cell tips [4Wachtler V. Rajagopalan S. Balasubramanian M.K. Sterol-rich plasma membrane domains in the fission yeast Schizosaccharomyces pombe.J. Cell Sci. 2003; 116: 867-874Crossref PubMed Scopus (138) Google Scholar]. Here, we show that the sole S. pombe myosin I, myo1p, is required for proper organization of these membrane domains. myo1 mutants lacking the TH1 domain exhibit a uniform distribution of sterol-rich membranes all over the plasma membrane throughout the cell cycle. These effects are independent of endocytosis because myo1 mutants exhibit no endocytic defects. Conversely, overexpression of myo1p induces ectopic sterol-rich membrane domains. Myo1p localizes to nonmotile foci that cluster in sterol-rich plasma membrane domains and fractionates with detergent-resistant membranes. Because the myo1p TH1 domain may bind directly to acidic phospholipids, these findings suggest a model for how type I myosin contributes to the organization of specialized membrane domains." @default.
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• W2069685280 date "2005-07-01" @default.
• W2069685280 modified "2023-09-23" @default.
• W2069685280 title "Role of Fission Yeast Myosin I in Organization of Sterol-Rich Membrane Domains" @default.
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• W2069685280 doi "https://doi.org/10.1016/j.cub.2005.07.009" @default.
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