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• W2069694248 abstract "Experimental and theoretical studies have showed that the native-state topology conceals a wealth of information about protein folding/unfolding. In this study, a method based on the Gaussian network model (GNM) is developed to study some properties of protein unfolding and explore the role of topology in protein unfolding process. The GNM has been successful in predicting atomic fluctuations around an energy minimum. However, in the GNM, the normal mode description is linear and cannot be accurate in studying protein folding/unfolding, which has many local minima in the energy landscape. To describe the nonlinearity of the conformational changes during protein unfolding, a method based on the iterative use of normal mode calculation is proposed. The protein unfolding process is mimicked through breaking the native contacts between the residues one by one according to the fluctuations of the distance between them. With this approach, the unfolding processes of two proteins, CI2 and barnase, are simulated. It is found that the sequence of protein unfolding events revealed by this method is consistent with that obtained from thermal unfolding by molecular dynamics and Monte Carlo simulations. The results indicate that this method is effective in studying protein unfolding. In this method, only the native contacts are considered, which implies that the native topology may play an important role in the protein unfolding process. The simulation results also show that the unfolding pathway is robust against the introduction of some noise, or stochastic characters. Furthermore, several conformations selected from the unfolding process are studied to show that the denatured state does not behave as a random coil, but seems to have highly cooperative motions, which may help and promote the polypeptide chain to fold into the native state correctly and speedily." @default.
• W2069694248 created "2016-06-24" @default.
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• W2069694248 date "2008-06-01" @default.
• W2069694248 modified "2023-10-12" @default.
• W2069694248 title "Protein Unfolding Behavior Studied by Elastic Network Model" @default.
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• W2069694248 cites W1977428203 @default.
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• W2069694248 doi "https://doi.org/10.1529/biophysj.107.121665" @default.
• W2069694248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2397338" @default.
• W2069694248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18310247" @default.
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