FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069701590> ?p ?o ?g. }

• W2069701590 endingPage "341" @default.
• W2069701590 startingPage "332" @default.
• W2069701590 abstract "Lyophilized formulations of keratinocyte growth factor-2 (KGF-2) were prepared with a range of disaccharide (sucrose or trehalose) and hydroxyethyl starch (HES) mass ratios. Protein degradation was assessed as a function of time of storage of the dried formulations at 40, 50 and 60 °C. Lyophilized and stored samples were rehydrated, and protein degradation was quantified by measuring loss of monomeric protein with size exclusion chromatography and by determining chemical degradation in the soluble fraction with reverse-phase chromatography. The secondary structure of the protein in the lyophilized formulations was studied with infrared spectroscopy. The magnitudes of degradation were compared the key physical properties of the formulations including retention of protein native secondary structure, glass transition temperature (Tg), inverse mean square displacements 〈u2〉−1 for hydrogen atoms (fast β relaxation), and the relaxation time τβ, which correlates with relaxation due to fast Johari–Goldstein motions in the glass (Xu et al., 2013) [1]. In addition, specific surface areas of the lyophilized formulations were determined by Brunauer–Emmet–Teller analysis of krypton adsorption isotherms and used to estimate the fraction of the KGF-2 molecules residing at the solid–air interface. KGF-2 degradation rates were highest in formulations wherein the protein’s structure was most perturbed, and wherein β relaxations were fastest, but the dominant factor governing KGF-2 degradation in freeze-dried formulations was the fraction of the protein found at the glass solid–air interface." @default.
• W2069701590 created "2016-06-24" @default.
• W2069701590 creator A5001572718 @default.
• W2069701590 creator A5004607792 @default.
• W2069701590 creator A5008365437 @default.
• W2069701590 creator A5012997643 @default.
• W2069701590 creator A5032689850 @default.
• W2069701590 creator A5060968038 @default.
• W2069701590 date "2014-10-01" @default.
• W2069701590 modified "2023-09-26" @default.
• W2069701590 title "Storage stability of keratinocyte growth factor-2 in lyophilized formulations: Effects of formulation physical properties and protein fraction at the solid–air interface" @default.
• W2069701590 cites W1276324155 @default.
• W2069701590 cites W1542001620 @default.
• W2069701590 cites W1602974455 @default.
• W2069701590 cites W1968373450 @default.
• W2069701590 cites W1971328795 @default.
• W2069701590 cites W1971414656 @default.
• W2069701590 cites W1974066967 @default.
• W2069701590 cites W1977805806 @default.
• W2069701590 cites W1977996370 @default.
• W2069701590 cites W1979739531 @default.
• W2069701590 cites W1988089792 @default.
• W2069701590 cites W198888838 @default.
• W2069701590 cites W1994863979 @default.
• W2069701590 cites W2004030954 @default.
• W2069701590 cites W2011254969 @default.
• W2069701590 cites W2023098204 @default.
• W2069701590 cites W2035740542 @default.
• W2069701590 cites W2043784518 @default.
• W2069701590 cites W2047125616 @default.
• W2069701590 cites W2054101065 @default.
• W2069701590 cites W2055974743 @default.
• W2069701590 cites W2066662804 @default.
• W2069701590 cites W2075369467 @default.
• W2069701590 cites W2075746219 @default.
• W2069701590 cites W2078714382 @default.
• W2069701590 cites W2079274958 @default.
• W2069701590 cites W2083951623 @default.
• W2069701590 cites W2087399617 @default.
• W2069701590 cites W2091595825 @default.
• W2069701590 cites W2106743573 @default.
• W2069701590 cites W2130542921 @default.
• W2069701590 cites W2159426997 @default.
• W2069701590 cites W2166622100 @default.
• W2069701590 cites W2170373214 @default.
• W2069701590 cites W94229796 @default.
• W2069701590 doi "https://doi.org/10.1016/j.ejpb.2014.05.012" @default.
• W2069701590 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4240752" @default.
• W2069701590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24859390" @default.
• W2069701590 hasPublicationYear "2014" @default.
• W2069701590 type Work @default.
• W2069701590 sameAs 2069701590 @default.
• W2069701590 citedByCount "23" @default.
• W2069701590 countsByYear W20697015902015 @default.
• W2069701590 countsByYear W20697015902016 @default.
• W2069701590 countsByYear W20697015902017 @default.
• W2069701590 countsByYear W20697015902018 @default.
• W2069701590 countsByYear W20697015902019 @default.
• W2069701590 countsByYear W20697015902020 @default.
• W2069701590 countsByYear W20697015902021 @default.
• W2069701590 countsByYear W20697015902022 @default.
• W2069701590 countsByYear W20697015902023 @default.
• W2069701590 crossrefType "journal-article" @default.
• W2069701590 hasAuthorship W2069701590A5001572718 @default.
• W2069701590 hasAuthorship W2069701590A5004607792 @default.
• W2069701590 hasAuthorship W2069701590A5008365437 @default.
• W2069701590 hasAuthorship W2069701590A5012997643 @default.
• W2069701590 hasAuthorship W2069701590A5032689850 @default.
• W2069701590 hasAuthorship W2069701590A5060968038 @default.
• W2069701590 hasBestOaLocation W20697015902 @default.
• W2069701590 hasConcept C113196181 @default.
• W2069701590 hasConcept C149629883 @default.
• W2069701590 hasConcept C170493617 @default.
• W2069701590 hasConcept C178790620 @default.
• W2069701590 hasConcept C181199279 @default.
• W2069701590 hasConcept C185592680 @default.
• W2069701590 hasConcept C193363816 @default.
• W2069701590 hasConcept C2775960820 @default.
• W2069701590 hasConcept C2778615670 @default.
• W2069701590 hasConcept C2779679103 @default.
• W2069701590 hasConcept C41008148 @default.
• W2069701590 hasConcept C43617362 @default.
• W2069701590 hasConcept C55493867 @default.
• W2069701590 hasConcept C76155785 @default.
• W2069701590 hasConcept C84199377 @default.
• W2069701590 hasConceptScore W2069701590C113196181 @default.
• W2069701590 hasConceptScore W2069701590C149629883 @default.
• W2069701590 hasConceptScore W2069701590C170493617 @default.
• W2069701590 hasConceptScore W2069701590C178790620 @default.
• W2069701590 hasConceptScore W2069701590C181199279 @default.
• W2069701590 hasConceptScore W2069701590C185592680 @default.
• W2069701590 hasConceptScore W2069701590C193363816 @default.
• W2069701590 hasConceptScore W2069701590C2775960820 @default.
• W2069701590 hasConceptScore W2069701590C2778615670 @default.
• W2069701590 hasConceptScore W2069701590C2779679103 @default.
• W2069701590 hasConceptScore W2069701590C41008148 @default.
• W2069701590 hasConceptScore W2069701590C43617362 @default.
• W2069701590 hasConceptScore W2069701590C55493867 @default.

• next