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• W2069705414 startingPage "8063" @default.
• W2069705414 abstract "Astrocytes release ATP and glutamate through vesicular exocytosis to mediate neuron–glial interactions. In contrast to exocytosis, the endocytic pathways in astroglial cells are poorly understood. Here, we identify a constitutive endocytic pathway in cultured astrocytes that is dependent on neither clathrin nor dynamin. This dynamin-independent endocytic pathway is regulated by Rab5, an early endosome protein. The endocytosed vesicles show fast transition from early endosomes to late endosomes and lysosomes within a few minutes. Interestingly, this clathrin- and dynamin-independent endocytosis in astrocytes is potently regulated by intracellular Ca²⁺. ATP and glutamate greatly enhance the dynamin-independent endocytosis through elevating the intracellular Ca²⁺. In addition, amyloid-β peptide (Aβ) also enhances the dynamin-independent endocytosis by inducing Ca²⁺ transients in astrocytes. These results demonstrate a novel endocytic pathway in glial cells that is dynamin independent but tightly regulated by intracellular Ca²⁺. The regulation by ATP, glutamate, and Aβ suggests an important role of the dynamin-independent endocytosis in both physiological and pathological conditions." @default.
• W2069705414 created "2016-06-24" @default.
• W2069705414 creator A5045550508 @default.
• W2069705414 creator A5068918837 @default.
• W2069705414 date "2009-06-24" @default.
• W2069705414 modified "2023-10-03" @default.
• W2069705414 title "Ca2+ Regulation of Dynamin-Independent Endocytosis in Cortical Astrocytes" @default.
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• W2069705414 doi "https://doi.org/10.1523/jneurosci.6139-08.2009" @default.
• W2069705414 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6666031" @default.
• W2069705414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19553446" @default.
• W2069705414 hasPublicationYear "2009" @default.
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