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- W2069706904 abstract "The present study was to investigate the role of microRNA (miR)-211-5p on cerebral ischemia–reperfusion injury (CIRI) and clarify its underlying mechanisms. Middle cerebral artery occlusion/reperfusion (MCAO/R) was operated on male Sprague Dawley (SD) rats, oxygen-glucose deprivation/reperfusion (OGD/R) was conducted on pheochromocytoma-12 (PC12) cells. Here, we found that miR-211-5p and Cyclooxygenase (COX2) expressions were altered in the plasma, cortex and hippocampus of MCAO/R-treated rats, as well as in the OGD/R-treaded PC12 cells. In vivo, overexpression of miR-211-5p resulted in decrease of infarct volumes, neurological deficit scores and histopathological damage. In vitro, miR-211-5p overexpression significantly decreased cell apoptosis and Lactate dehydrogenase (LDH) release rate, increased cell viability. Furthermore, our data showed that miR-211-5p overexpression markedly reduced the expressions of COX2 mRNA and protein, and the contents of Prostaglandin D2 (PGD2), PGE2, tumor necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β). In addition, inhibition of COX2 significantly rescued the effects of miR-211-5p inhibitor. At last, dual luciferase experimental data showed that miR-211-5p regulated the mRNA stability of COX2 by directly binding to the 3′-untranslated region (3′-UTR) of COX2. In conclusion, our data suggested the neuroprotective effects of miR-211-5p on CIRI by targeting COX2." @default.
- W2069706904 created "2016-06-24" @default.
- W2069706904 creator A5000433513 @default.
- W2069706904 creator A5017624919 @default.
- W2069706904 date "1985-01-01" @default.
- W2069706904 modified "2023-10-10" @default.
- W2069706904 title "Behavioral and neurochemical aspects of prostaglandins in brain function" @default.
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- W2069706904 doi "https://doi.org/10.1016/0306-3623(85)90064-3" @default.
- W2069706904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2991073" @default.
- W2069706904 hasPublicationYear "1985" @default.
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