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W2069712437 abstract "We characterized agonist-induced internalization, recycling and downregulation of each muscarinic receptor subtype (M1–M5) stably expressed in Chinese hamster ovary (CHO) cells. The radioligands [3H]QNB and [3H]NMS were used to measure the total and plasma membrane populations of muscarinic receptors, respectively. Following carbachol treatment (1 mM), the rank orders for the rate of carbachol-induced internalization of the muscarinic subtypes were M2 > M4 = M5 > M3 = M1, respectively. Unlike the M2 receptor, M1, M3, M4 and M5 receptors recycled back to the plasma membrane after 1 h carbachol treatment. The receptor downregulation elicited to 24 h carbachol treatment was similar for M2, M3, M4 and M5 receptors, whereas that for the M1 receptor was greater. Our results indicate that there are subtype-specific differences in the rate and extent of agonist-induced muscarinic receptor internalization, recycling and downregulation in CHO cells." @default.
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W2069712437 date "2011-01-01" @default.
W2069712437 modified "2023-09-24" @default.
W2069712437 title "Comparison of the kinetics and extent of muscarinic M1–M5 receptor internalization, recycling and downregulation in Chinese hamster ovary cells" @default.
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W2069712437 doi "https://doi.org/10.1016/j.ejphar.2010.10.054" @default.
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