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- W2069714920 abstract "Vinculin helps cells regulate and respond to mechanical forces. It is a scaffolding protein that tightly regulates its interactions with potential binding partners within adhesive structures-including focal adhesions that link the cell to the extracellular matrix and adherens junctions that link cells to each other-that physically connect the force-generating actin cytoskeleton (CSK) with the extracellular environment. This tight control of binding partner interaction-mediated by vinculin's autoinhibitory head-tail interaction-allows vinculin to rapidly interact and detach in response to changes in the dynamic forces applied through the cell. In doing so, vinculin modulates the structural composition of focal adhesions and the cell's ability to generate traction forces and adhesion strength. Recent evidence suggests that vinculin plays a similar role in regulating the fate and function of cell-cell junctions, further underscoring the importance of this protein. Using our lab's recent work as a starting point, this commentary explores several outstanding questions regarding the nature of vinculin activation and its function within focal adhesions and adherens junctions." @default.
- W2069714920 created "2016-06-24" @default.
- W2069714920 creator A5011208920 @default.
- W2069714920 creator A5061535468 @default.
- W2069714920 date "2014-10-31" @default.
- W2069714920 modified "2023-10-12" @default.
- W2069714920 title "A helping hand: How vinculin contributes to cell-matrix and cell-cell force transfer" @default.
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- W2069714920 doi "https://doi.org/10.4161/cam.29139" @default.
- W2069714920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4594512" @default.
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