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• W2069719074 abstract "Infants with passively transferred maternal antibody (PMA) to hepatitis A virus (HAV) have lower concentrations of antibody to HAV (anti-HAV) after vaccination. We examined the effect of PMA on persistence of anti-HAV and on immune memory.We measured anti-HAV concentrations of 6-year-old children who had responded to a three dose hepatitis A vaccine series at ages 2, 4 and 6 months. Group 1 children were born to anti-HAV-negative women; Group 2 children had anti-HAV-positive mothers and PMA at 2 months of age. Children without detectable antibody at 6-year follow-up were offered a booster dose [360 enzyme-linked immunosorbent units (ELU)]. An anamnestic response was defined as a postbooster anti-HAV concentration of > or =400 mIU/ml.At follow-up, before the booster dose, Group 1 subjects had a higher geometric mean concentration (50 mIU/ml vs.18 mIU/ml, P = 0.007), and a larger proportion retained seroprotective concentrations of anti-HAV [21 of 31 (68%) vs.4 of 17 (24%)] compared with Group 2 subjects. The two stage antibody decline curves for the two groups from 8 months old to follow-up testing were parallel. An anamnestic response occurred in all (5 of 5) Group 1 and 67% (4 of 6) of Group 2 children. The geometric mean antibody concentrations after the booster were 1102 and 406 mIU/ml for Groups 1 and 2, respectively (P = 0.10).Infants with PMA who receive hepatitis A vaccine have significantly lower concentrations of anti-HAV 6 years later than infants with no PMA who receive hepatitis A vaccine. Immune memory may remain functional despite these lower anti-HAV concentrations." @default.
• W2069719074 created "2016-06-24" @default.
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• W2069719074 date "2003-04-01" @default.
• W2069719074 modified "2023-10-14" @default.
• W2069719074 title "Hepatitis A vaccination of infants: effect of maternal antibody status on antibody persistence and response to a booster dose" @default.
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• W2069719074 doi "https://doi.org/10.1097/01.inf.0000059446.52063.b9" @default.
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