Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069721695> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2069721695 endingPage "395" @default.
- W2069721695 startingPage "387" @default.
- W2069721695 abstract "1 Positive chronotropic and inotropic myocardial responses to different adrenoreceptor agonists were studied using isolated right atria and left ventricular papillary muscles from rats treated orally for 5 weeks with prazosin, an α1-antagonist, or vehicle (distilled water). 2 Chronotropic responses to the α-adrenoreceptor agonists isoprenaline and salbutamol were similar in atria from both groups of rats, with no differences in their basal rates, maximum rate increases or pD2 values for either agonist. 3 Basal contractile force of field-stimulated papillary muscles was similar in both prazosin-treated (0.089 ± 0.014 g mg-1) and control groups (0.104 ± 0.035 g mg-1). In response to noradrenaline, force increased maximally by 145 ± 30% and 131 ± 30% above resting levels respectively, and pD2 values for this β- and α-agonist showed no changes after chronic prazosin treatment. Inotropic responses to isoprenaline were also not different with maximum increases in force of 94.5 ± 20.2% for prazosin-treated and 84.5 ± 18.5% for controls, and similar pD2 values. 4 However, in response to the α-agonist phenylephrine (in the presence of propranolol), maximum increases in force were greater in relation to the noradrenaline maxima after prazosin treatment (48.8 ± 4.2%) than in controls (32.0 ± 4.3%, P<0.02). pD2 values for phenylephrine were also significantly higher after long-term α-blockade (5.71 ± 0.10 vs 5.30 ± 0.19 for controls, P<0.05). 5 Long-term α-blockade in the rat therefore led to supersensitivity of α-mediated inotropism in the heart, but both β-mediated inotropic and chronotropic responses were unaffected. These results show selectivity of action of chronic prazosin treatment on α-receptors in the rat heart." @default.
- W2069721695 created "2016-06-24" @default.
- W2069721695 creator A5091817615 @default.
- W2069721695 date "1989-12-01" @default.
- W2069721695 modified "2023-09-23" @default.
- W2069721695 title "Myocardial chronotropic and inotropic responsiveness in vitro after chronic α-adrenoreceptor blockade in the rat" @default.
- W2069721695 cites W1965740043 @default.
- W2069721695 cites W1971875781 @default.
- W2069721695 cites W1977956094 @default.
- W2069721695 cites W1980702154 @default.
- W2069721695 cites W1987265099 @default.
- W2069721695 cites W1989282030 @default.
- W2069721695 cites W1989786199 @default.
- W2069721695 cites W1998514229 @default.
- W2069721695 cites W2031778869 @default.
- W2069721695 cites W2033396087 @default.
- W2069721695 cites W2036204835 @default.
- W2069721695 cites W2044354013 @default.
- W2069721695 cites W2044696801 @default.
- W2069721695 cites W2049531852 @default.
- W2069721695 cites W2049790354 @default.
- W2069721695 cites W2078011767 @default.
- W2069721695 cites W2081571634 @default.
- W2069721695 cites W2081582499 @default.
- W2069721695 cites W2089124522 @default.
- W2069721695 cites W2089909892 @default.
- W2069721695 cites W2103557531 @default.
- W2069721695 cites W2106705252 @default.
- W2069721695 cites W2146907325 @default.
- W2069721695 cites W2155318267 @default.
- W2069721695 cites W4211208767 @default.
- W2069721695 doi "https://doi.org/10.1111/j.1474-8673.1989.tb00498.x" @default.
- W2069721695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2576022" @default.
- W2069721695 hasPublicationYear "1989" @default.
- W2069721695 type Work @default.
- W2069721695 sameAs 2069721695 @default.
- W2069721695 citedByCount "1" @default.
- W2069721695 crossrefType "journal-article" @default.
- W2069721695 hasAuthorship W2069721695A5091817615 @default.
- W2069721695 hasConcept C126322002 @default.
- W2069721695 hasConcept C134018914 @default.
- W2069721695 hasConcept C155710745 @default.
- W2069721695 hasConcept C158328960 @default.
- W2069721695 hasConcept C170493617 @default.
- W2069721695 hasConcept C185592680 @default.
- W2069721695 hasConcept C24998067 @default.
- W2069721695 hasConcept C2776090920 @default.
- W2069721695 hasConcept C2776885963 @default.
- W2069721695 hasConcept C2777952589 @default.
- W2069721695 hasConcept C2777953023 @default.
- W2069721695 hasConcept C2778151854 @default.
- W2069721695 hasConcept C2778468042 @default.
- W2069721695 hasConcept C2778938600 @default.
- W2069721695 hasConcept C2780648677 @default.
- W2069721695 hasConcept C71924100 @default.
- W2069721695 hasConcept C84393581 @default.
- W2069721695 hasConceptScore W2069721695C126322002 @default.
- W2069721695 hasConceptScore W2069721695C134018914 @default.
- W2069721695 hasConceptScore W2069721695C155710745 @default.
- W2069721695 hasConceptScore W2069721695C158328960 @default.
- W2069721695 hasConceptScore W2069721695C170493617 @default.
- W2069721695 hasConceptScore W2069721695C185592680 @default.
- W2069721695 hasConceptScore W2069721695C24998067 @default.
- W2069721695 hasConceptScore W2069721695C2776090920 @default.
- W2069721695 hasConceptScore W2069721695C2776885963 @default.
- W2069721695 hasConceptScore W2069721695C2777952589 @default.
- W2069721695 hasConceptScore W2069721695C2777953023 @default.
- W2069721695 hasConceptScore W2069721695C2778151854 @default.
- W2069721695 hasConceptScore W2069721695C2778468042 @default.
- W2069721695 hasConceptScore W2069721695C2778938600 @default.
- W2069721695 hasConceptScore W2069721695C2780648677 @default.
- W2069721695 hasConceptScore W2069721695C71924100 @default.
- W2069721695 hasConceptScore W2069721695C84393581 @default.
- W2069721695 hasIssue "6" @default.
- W2069721695 hasLocation W20697216951 @default.
- W2069721695 hasLocation W20697216952 @default.
- W2069721695 hasOpenAccess W2069721695 @default.
- W2069721695 hasPrimaryLocation W20697216951 @default.
- W2069721695 hasRelatedWork W1984748936 @default.
- W2069721695 hasRelatedWork W2005881152 @default.
- W2069721695 hasRelatedWork W2052706297 @default.
- W2069721695 hasRelatedWork W2069721695 @default.
- W2069721695 hasRelatedWork W2140322185 @default.
- W2069721695 hasRelatedWork W2257354174 @default.
- W2069721695 hasRelatedWork W2403988730 @default.
- W2069721695 hasRelatedWork W2411297412 @default.
- W2069721695 hasRelatedWork W2411476455 @default.
- W2069721695 hasRelatedWork W2163452314 @default.
- W2069721695 hasVolume "9" @default.
- W2069721695 isParatext "false" @default.
- W2069721695 isRetracted "false" @default.
- W2069721695 magId "2069721695" @default.
- W2069721695 workType "article" @default.