FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069723920> ?p ?o ?g. }

• W2069723920 endingPage "653" @default.
• W2069723920 startingPage "643" @default.
• W2069723920 abstract "It is concluded from many experiments that mammalian tissues and cells must contain a heterogeneous population of 20 S proteasome complexes. We describe the purification and separation by chromatographic procedures of constitutive 20 S proteasomes, 20 S immuno-proteasomes and intermediate-type 20 S proteasomes from a given tissue. Our data demonstrate that each of these three groups comprises more than one subtype and that the relative ratios of the subtypes differ between different rat tissues. Thus, six subtypes could be identified in rat muscle tissue. Subtypes I and II are constitutive proteasomes, while subtypes V and VI comprise immuno-proteasomes. Subtypes III and IV belong to a group of intermediate-type proteasomes. The subtypes differ with regard to their enzymatic characteristics. Subtypes I-III exhibit high chymotrypsin-like activity and high peptidylglutamylpeptide hydrolysing activity, while these activities are depressed in subtypes IV-VI. In contrast, trypsin-like activity of subtypes IV-VI is enhanced in comparison to subtypes I-III. Importantly, the subtypes also differ in their preferential cleavage site usage when tested by digestion of a synthetic 25mer polypeptide substrate. Therefore, the characteristics of proteasomes purified from tissues or cells represent the average of the different subtype activities which in turn may have different functions in vivo." @default.
• W2069723920 created "2016-06-24" @default.
• W2069723920 creator A5039016583 @default.
• W2069723920 creator A5046137886 @default.
• W2069723920 creator A5048863938 @default.
• W2069723920 creator A5070423926 @default.
• W2069723920 creator A5077631702 @default.
• W2069723920 date "2000-11-01" @default.
• W2069723920 modified "2023-10-18" @default.
• W2069723920 title "Different proteasome subtypes in a single tissue exhibit different enzymatic properties 1 1Edited by R. Huber" @default.
• W2069723920 cites W1510475344 @default.
• W2069723920 cites W1520570018 @default.
• W2069723920 cites W1541794688 @default.
• W2069723920 cites W165358662 @default.
• W2069723920 cites W1856494664 @default.
• W2069723920 cites W192390236 @default.
• W2069723920 cites W1960514362 @default.
• W2069723920 cites W1989562949 @default.
• W2069723920 cites W1989619172 @default.
• W2069723920 cites W1991930087 @default.
• W2069723920 cites W1995000827 @default.
• W2069723920 cites W1999814371 @default.
• W2069723920 cites W2004180892 @default.
• W2069723920 cites W2023687151 @default.
• W2069723920 cites W2031286256 @default.
• W2069723920 cites W2031623763 @default.
• W2069723920 cites W2038100174 @default.
• W2069723920 cites W2048375884 @default.
• W2069723920 cites W2049430963 @default.
• W2069723920 cites W2060582345 @default.
• W2069723920 cites W2070316569 @default.
• W2069723920 cites W2072967102 @default.
• W2069723920 cites W2073226772 @default.
• W2069723920 cites W2082522376 @default.
• W2069723920 cites W2083453910 @default.
• W2069723920 cites W2100837269 @default.
• W2069723920 cites W2104710873 @default.
• W2069723920 cites W2114163044 @default.
• W2069723920 cites W2115270691 @default.
• W2069723920 cites W2116595225 @default.
• W2069723920 cites W2122515314 @default.
• W2069723920 cites W2159274617 @default.
• W2069723920 cites W2178503716 @default.
• W2069723920 cites W2412215521 @default.
• W2069723920 doi "https://doi.org/10.1006/jmbi.2000.4185" @default.
• W2069723920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11061965" @default.
• W2069723920 hasPublicationYear "2000" @default.
• W2069723920 type Work @default.
• W2069723920 sameAs 2069723920 @default.
• W2069723920 citedByCount "187" @default.
• W2069723920 countsByYear W20697239202012 @default.
• W2069723920 countsByYear W20697239202013 @default.
• W2069723920 countsByYear W20697239202014 @default.
• W2069723920 countsByYear W20697239202015 @default.
• W2069723920 countsByYear W20697239202016 @default.
• W2069723920 countsByYear W20697239202017 @default.
• W2069723920 countsByYear W20697239202018 @default.
• W2069723920 countsByYear W20697239202019 @default.
• W2069723920 countsByYear W20697239202020 @default.
• W2069723920 countsByYear W20697239202021 @default.
• W2069723920 countsByYear W20697239202022 @default.
• W2069723920 countsByYear W20697239202023 @default.
• W2069723920 crossrefType "journal-article" @default.
• W2069723920 hasAuthorship W2069723920A5039016583 @default.
• W2069723920 hasAuthorship W2069723920A5046137886 @default.
• W2069723920 hasAuthorship W2069723920A5048863938 @default.
• W2069723920 hasAuthorship W2069723920A5070423926 @default.
• W2069723920 hasAuthorship W2069723920A5077631702 @default.
• W2069723920 hasConcept C144024400 @default.
• W2069723920 hasConcept C149923435 @default.
• W2069723920 hasConcept C151730666 @default.
• W2069723920 hasConcept C153911025 @default.
• W2069723920 hasConcept C175156509 @default.
• W2069723920 hasConcept C181199279 @default.
• W2069723920 hasConcept C185592680 @default.
• W2069723920 hasConcept C207001950 @default.
• W2069723920 hasConcept C27740335 @default.
• W2069723920 hasConcept C2776714187 @default.
• W2069723920 hasConcept C2778401398 @default.
• W2069723920 hasConcept C2780340462 @default.
• W2069723920 hasConcept C2781307694 @default.
• W2069723920 hasConcept C2908647359 @default.
• W2069723920 hasConcept C2994592520 @default.
• W2069723920 hasConcept C43369102 @default.
• W2069723920 hasConcept C54355233 @default.
• W2069723920 hasConcept C55493867 @default.
• W2069723920 hasConcept C86803240 @default.
• W2069723920 hasConceptScore W2069723920C144024400 @default.
• W2069723920 hasConceptScore W2069723920C149923435 @default.
• W2069723920 hasConceptScore W2069723920C151730666 @default.
• W2069723920 hasConceptScore W2069723920C153911025 @default.
• W2069723920 hasConceptScore W2069723920C175156509 @default.
• W2069723920 hasConceptScore W2069723920C181199279 @default.
• W2069723920 hasConceptScore W2069723920C185592680 @default.
• W2069723920 hasConceptScore W2069723920C207001950 @default.
• W2069723920 hasConceptScore W2069723920C27740335 @default.
• W2069723920 hasConceptScore W2069723920C2776714187 @default.
• W2069723920 hasConceptScore W2069723920C2778401398 @default.

• next