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• W2069737818 abstract "The tryptophan biosynthetic operon has been widely used as a model system for studying transcription regulation. In Bacillus subtilis, the trp operon is primarily regulated by a tryptophan-activated RNA-binding protein, TRAP. Here we show that in many other Gram-positive species the trp operon is regulated differently, by tRNATrp sensing by the RNA-based T-box mechanism, with T-boxes arranged in tandem. Our analyses reveal an apparent relationship between trp operon organization and the specific regulatory mechanism(s) used. The tryptophan biosynthetic operon has been widely used as a model system for studying transcription regulation. In Bacillus subtilis, the trp operon is primarily regulated by a tryptophan-activated RNA-binding protein, TRAP. Here we show that in many other Gram-positive species the trp operon is regulated differently, by tRNATrp sensing by the RNA-based T-box mechanism, with T-boxes arranged in tandem. Our analyses reveal an apparent relationship between trp operon organization and the specific regulatory mechanism(s) used. an anti-TRAP protein that specifically recognizes Trp-activated TRAP and can bind to its surface, preventing TRAP from binding to RNA. (from the Greek khloros, light green, and the Latin flexus, to bend, meaning green filamentous bacteria) these bacteria, formerly known as green non-sulfur bacteria, produce energy using photosynthesis. They are named for their green pigment and filamentous shape, are facultative aerobes, but do not produce oxygen during photosynthesis. the sole precursor of the three aromatic amino acids, phenylalanine, tyrosine and tryptophan, and the precursor of p-aminobenzoic acid, a component of folic acid. (from the Latin firmus, strong, and cutis, skin, meaning bacteria with a strong cell wall) these bacteria represent a division originally including all Gram-positive bacteria. The members do not have the second membrane of Gram-negative bacteria, although some do not respond to Gram staining because they also lack a cell wall. The term Firmicutes is now used to describe the so-called ‘low G + C’ group, in contrast to the ‘high G + C’ Actinobacteria. Firmicutes can be subdivided into the anaerobic Clostridia, the Bacillales, which are obligate or facultative aerobes, and the Mollicutes, which are obligate parasites with minimal genomes. refers to gene location and gene neighbors of a specific genetic locus. Analysis of genomic context has been widely used to predict the functions of novel genes. an RNA sequence that adopts a folded conformation enabling recognition of a specific uncharged tRNA. The uncharged tRNA pairs to this RNA by codon–anticodon pairing, and by pairing of its acceptor end to the T-box sequence. tRNA pairing with the T-box results in stabilization of the antiterminator structure, thereby preventing formation of the terminator, and preventing transcription termination. a regulatory mechanism involving the formation of either of two alternative RNA structures, a transcription terminator, or a transcription antiterminator. Formation of the terminator causes transcription termination. a tryptophan-activated RNA binding protein. When TRAP binds to an RNA ‘TRAP-binding site’ it either causes transcription termination or inhibits translation initiation." @default.
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• W2069737818 date "2007-09-01" @default.
• W2069737818 modified "2023-10-15" @default.
• W2069737818 title "Comparison of tryptophan biosynthetic operon regulation in different Gram-positive bacterial species" @default.
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• W2069737818 doi "https://doi.org/10.1016/j.tig.2007.05.005" @default.
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