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- W2069741555 endingPage "590" @default.
- W2069741555 startingPage "537" @default.
- W2069741555 abstract "The basis for understanding clinical disorders in the neuroregulation of GH secretion is derived from the complexity of the CNS-hypothalamic-pituitary axis. Studies in animals and humans demonstrate an anatomic, physiological and pharmacological evidence for neurosecretory control over GH secretion including neurohormones (GRH, somatostatin), neurotransmitters (dopaminergic, adrenergic, cholinergic, serotonergic, histaminergic, GABAergic), and neuropeptides (gut hormones, opioids, CRH, TRH, etc). The observation of a defect in the neuroregulatory control of GH secretion in CNS-irradiated humans and animals led to the hypothesis of a disorder in neurosecretion, GHND, as a cause for short stature. We speculate that in this heterogeneous group of children a disruption in the neurotransmitter-neurohormonal functional pathway could modify secretion ultimately expressed as poor growth velocity and short stature." @default.
- W2069741555 created "2016-06-24" @default.
- W2069741555 creator A5017331074 @default.
- W2069741555 creator A5072621143 @default.
- W2069741555 date "1986-08-01" @default.
- W2069741555 modified "2023-10-05" @default.
- W2069741555 title "6 Growth hormone neurosecretory dysfunction" @default.
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