Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069759172> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2069759172 endingPage "295" @default.
- W2069759172 startingPage "290" @default.
- W2069759172 abstract "An inhibitor to the muscarinic acetylcholine receptor (mAChR) was purified from the venom of Crotalus atrox (western diamondback rattlesnake). The inhibitor was found to be a 30-kDa homodimer protein with phospholipase A2 activity. In order to determine the subtype selectivity of the purified inhibitor, the inhibitory effect on the binding of two orthosteric antagonists, [3H]quinuclidinyl benzilate ([3H]QNB) and [3H]N-methylscopolamine methyl chloride ([3H]NMS), to five subtypes of cloned human mAChR was tested. The purified inhibitor reduced the binding of [3H]QNB and/or [3H]NMS to all subtypes of the mAChR while showing the highest inhibitory effect on the M5 subtype. The Kd values of the receptors for the antagonists were increased in the presence of the inhibitor; however, the Bmax values were not changed. The effects of the purified inhibitor on the dissociation of [3H]NMS from the receptors were also investigated. Dissociation of the antagonist was remarkably slowed down by addition of the inhibitor. These findings may suggest an allosteric action of the purified inhibitor. In addition, the present study indicates that the presence of mAChR inhibitors is quite common in snake venoms." @default.
- W2069759172 created "2016-06-24" @default.
- W2069759172 creator A5004135057 @default.
- W2069759172 creator A5048918974 @default.
- W2069759172 date "2000-05-01" @default.
- W2069759172 modified "2023-10-06" @default.
- W2069759172 title "A Snake Venom Inhibitor to Muscarinic Acetylcholine Receptor (mAChR): Isolation and Interaction with Cloned Human mAChR" @default.
- W2069759172 cites W1980928041 @default.
- W2069759172 cites W1982772302 @default.
- W2069759172 cites W1983602960 @default.
- W2069759172 cites W1986126192 @default.
- W2069759172 cites W1986254612 @default.
- W2069759172 cites W2003655904 @default.
- W2069759172 cites W2018414456 @default.
- W2069759172 cites W2022528144 @default.
- W2069759172 cites W2037402278 @default.
- W2069759172 cites W2043813981 @default.
- W2069759172 cites W2049962729 @default.
- W2069759172 cites W2060989228 @default.
- W2069759172 cites W2069854818 @default.
- W2069759172 cites W2073808168 @default.
- W2069759172 cites W2087240492 @default.
- W2069759172 cites W2088728973 @default.
- W2069759172 cites W2120935005 @default.
- W2069759172 cites W2520597986 @default.
- W2069759172 doi "https://doi.org/10.1006/abbi.2000.1784" @default.
- W2069759172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10845706" @default.
- W2069759172 hasPublicationYear "2000" @default.
- W2069759172 type Work @default.
- W2069759172 sameAs 2069759172 @default.
- W2069759172 citedByCount "9" @default.
- W2069759172 countsByYear W20697591722012 @default.
- W2069759172 countsByYear W20697591722015 @default.
- W2069759172 crossrefType "journal-article" @default.
- W2069759172 hasAuthorship W2069759172A5004135057 @default.
- W2069759172 hasAuthorship W2069759172A5048918974 @default.
- W2069759172 hasConcept C116289061 @default.
- W2069759172 hasConcept C170493617 @default.
- W2069759172 hasConcept C185592680 @default.
- W2069759172 hasConcept C2776725428 @default.
- W2069759172 hasConcept C2776885963 @default.
- W2069759172 hasConcept C2778824757 @default.
- W2069759172 hasConcept C2779448229 @default.
- W2069759172 hasConcept C2908651707 @default.
- W2069759172 hasConcept C33789571 @default.
- W2069759172 hasConcept C47488739 @default.
- W2069759172 hasConcept C55493867 @default.
- W2069759172 hasConcept C80161118 @default.
- W2069759172 hasConcept C86803240 @default.
- W2069759172 hasConcept C98274493 @default.
- W2069759172 hasConceptScore W2069759172C116289061 @default.
- W2069759172 hasConceptScore W2069759172C170493617 @default.
- W2069759172 hasConceptScore W2069759172C185592680 @default.
- W2069759172 hasConceptScore W2069759172C2776725428 @default.
- W2069759172 hasConceptScore W2069759172C2776885963 @default.
- W2069759172 hasConceptScore W2069759172C2778824757 @default.
- W2069759172 hasConceptScore W2069759172C2779448229 @default.
- W2069759172 hasConceptScore W2069759172C2908651707 @default.
- W2069759172 hasConceptScore W2069759172C33789571 @default.
- W2069759172 hasConceptScore W2069759172C47488739 @default.
- W2069759172 hasConceptScore W2069759172C55493867 @default.
- W2069759172 hasConceptScore W2069759172C80161118 @default.
- W2069759172 hasConceptScore W2069759172C86803240 @default.
- W2069759172 hasConceptScore W2069759172C98274493 @default.
- W2069759172 hasIssue "2" @default.
- W2069759172 hasLocation W20697591721 @default.
- W2069759172 hasLocation W20697591722 @default.
- W2069759172 hasOpenAccess W2069759172 @default.
- W2069759172 hasPrimaryLocation W20697591721 @default.
- W2069759172 hasRelatedWork W1874406815 @default.
- W2069759172 hasRelatedWork W1909412610 @default.
- W2069759172 hasRelatedWork W1968051627 @default.
- W2069759172 hasRelatedWork W1973973669 @default.
- W2069759172 hasRelatedWork W2042321847 @default.
- W2069759172 hasRelatedWork W2086084124 @default.
- W2069759172 hasRelatedWork W2090550284 @default.
- W2069759172 hasRelatedWork W2141515004 @default.
- W2069759172 hasRelatedWork W2509635653 @default.
- W2069759172 hasRelatedWork W996612986 @default.
- W2069759172 hasVolume "377" @default.
- W2069759172 isParatext "false" @default.
- W2069759172 isRetracted "false" @default.
- W2069759172 magId "2069759172" @default.
- W2069759172 workType "article" @default.