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- W2069759271 abstract "Epidemiologic studies suggest that childhood viral exposures are important determinants of multiple sclerosis (MS) risk in both adults and children1 and, so far, Epstein-Barr virus (EBV) stands out as the infectious agent for which there is the most compelling evidence for an association with the disease.1–3### Patients, healthy donors, and methods.Twenty-three children with a diagnosis of definite MS and 17 demographically matched healthy peers were enrolled at the Department of Pediatrics and Pediatric Neurology, University of Gottingen, Germany (table e-1 on the Neurology ® Web site at www.neurology.org). Virus-specific antibody responses were assessed using standardized ELISA kits (Bio-Quant, San Diego, CA) for IgG antibodies directed against the EBV- encoded viral capsid antigen (EBV-VCA), the HCMV-derived early antigens (HCMV-EA), the immunogenic C-terminus of the latent EBV nuclear antigen-1 (EBNA1, aa 458-641), and toward EBV-infected B cell lysates.4 In order to assess the specificity of EBNA1-targeting IgG, 211 dodecamer peptides, overlapping by nine amino acids and covering the entire sequence of EBNA1 (aa 1-641), were covalently linked to cellulose membranes as described previously.5 Positive spots were identified as blue or purple. Individual membranes were processed and evaluated blinded to the clinical diagnosis.### Results.A total of 91% and 87% of MS cases compared to 64% and 58% of controls showed IgG responses toward EBV-VCA and EBNA1, respectively. The frequency of HCMV-EA seropositivity did not differ between both …" @default.
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- W2069759271 date "2008-09-22" @default.
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- W2069759271 title "BROADENED AND ELEVATED HUMORAL IMMUNE RESPONSE TO EBNA1 IN PEDIATRIC MULTIPLE SCLEROSIS" @default.
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- W2069759271 doi "https://doi.org/10.1212/01.wnl.0000326576.91097.87" @default.
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