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- W2069772910 abstract "The aim of this research was to develop a new hydrophilic matrix system containing norfloxacin (NFX). Extended-release tablets are usually intended for once-a-day administration with benefits to the patient and lower discontinuation of the therapy. Formulations were developed with hydroxypropylmethylcellulose or poly(ethylene oxide) as hydrophilic polymers, with different molecular weights (MWs) and concentrations (20 and 30%). The tablets were found to be stable (6 months at<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mn>40</mml:mn><mml:mo>±</mml:mo><mml:mn>2</mml:mn></mml:mrow></mml:math>°C and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mn>75</mml:mn><mml:mo>±</mml:mo><mml:mn>5</mml:mn></mml:mrow></mml:math>% relative humidity), and the film-coating process is recommended to avoid NFX photodegradation. The dissolution profiles demonstrated an extended-release of NFX for all developed formulations. Dissolution curves analyzed using the Korsmeyer exponential equation showed that drug release was controlled by both drug diffusion and polymer relaxation or erosion mechanisms. A more erosion controlled system was obtained for the formulations containing lower MW and amount of polymer. With the increase in both MW and amount of polymer in the formulation, the gel layer became stronger, and the dissolution was more drug-diffusion dependent. Formulations containing intermediate MW polymers or high concentration (30%) of low MW polymers demonstrated a combination of extended and complete in vitro drug release. This way, these formulations could provide an increased bioavailability in vivo." @default.
- W2069772910 created "2016-06-24" @default.
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- W2069772910 date "2013-01-01" @default.
- W2069772910 modified "2023-10-15" @default.
- W2069772910 title "Formulation Development and Stability Studies of Norfloxacin Extended-Release Matrix Tablets" @default.
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- W2069772910 doi "https://doi.org/10.1155/2013/716736" @default.
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