Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069773099> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2069773099 endingPage "562" @default.
- W2069773099 startingPage "549" @default.
- W2069773099 abstract "Steady state kinetic studies have provided evidence for intrinsic prothrombinase activity of human factor X zymogen in a chromogenic assay system. Using a prothrombin substrate, kinetic parameters have been obtained for the action of factors X and Xa. The Km for prothrombin is of a different order of magnitude for the zymogen as compared with the active enzyme. Using a kinetic approach, we have obtained evidence for the binding of factor Xa zymogen to cofactors essential for the coagulant activity of factor Xa. Zymogen enzymatic activity is not inhibited by a specific serine proteinase inhibitor, (p-amidino-phenyl)methanesulfonyl fluoride (p-APMSF), a potent inhibitor of factor Xa. The apparent slow rate of zymogen inhibition by antithrombin III (AT III) as compared with the active enzyme suggests a different kind of zymogen-antithrombin interaction. Blood clotting studies paralleled the kinetic data. Factor X zymogen evidences factor VIII inhibitor bypassing activity (FEIBA) in an in vitro direct clotting system employing factor VIII deficient inhibitor plasma as substrate in both activated or nonactivated partial thromboplastin assay. Most significantly, zymogen coagulant is refractory to inhibition by p-APMSF or AT III. We conclude that a system consisting of factor X zymogen-phospholipid-factor Va can physiologically initiate blood clotting in the presence of inhibitors and may have a major role in the bypass mechanism of therapeutic prothrombin complex concentrate (PCC)." @default.
- W2069773099 created "2016-06-24" @default.
- W2069773099 creator A5054697660 @default.
- W2069773099 creator A5088544339 @default.
- W2069773099 date "1984-12-01" @default.
- W2069773099 modified "2023-09-23" @default.
- W2069773099 title "Apparent intrinsic prothrombinase activity of human factor X zymogen: Identification with factor VIII inhibitor by passing activity (FEIBA)" @default.
- W2069773099 cites W142999592 @default.
- W2069773099 cites W1490507833 @default.
- W2069773099 cites W152180060 @default.
- W2069773099 cites W1543302782 @default.
- W2069773099 cites W1545489129 @default.
- W2069773099 cites W1625660792 @default.
- W2069773099 cites W184731395 @default.
- W2069773099 cites W2015038774 @default.
- W2069773099 cites W2032279957 @default.
- W2069773099 cites W2038045850 @default.
- W2069773099 cites W204538406 @default.
- W2069773099 cites W2056035582 @default.
- W2069773099 cites W2058530696 @default.
- W2069773099 cites W2074567743 @default.
- W2069773099 cites W2079865670 @default.
- W2069773099 cites W2080719447 @default.
- W2069773099 cites W2084199132 @default.
- W2069773099 cites W2093533880 @default.
- W2069773099 cites W2151938814 @default.
- W2069773099 cites W2171355105 @default.
- W2069773099 cites W2321411638 @default.
- W2069773099 cites W2403444710 @default.
- W2069773099 cites W2622928581 @default.
- W2069773099 cites W2734698134 @default.
- W2069773099 cites W3028099557 @default.
- W2069773099 cites W4247585786 @default.
- W2069773099 doi "https://doi.org/10.1016/0049-3848(84)90194-4" @default.
- W2069773099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6335607" @default.
- W2069773099 hasPublicationYear "1984" @default.
- W2069773099 type Work @default.
- W2069773099 sameAs 2069773099 @default.
- W2069773099 citedByCount "3" @default.
- W2069773099 countsByYear W20697730992012 @default.
- W2069773099 countsByYear W20697730992020 @default.
- W2069773099 crossrefType "journal-article" @default.
- W2069773099 hasAuthorship W2069773099A5054697660 @default.
- W2069773099 hasAuthorship W2069773099A5088544339 @default.
- W2069773099 hasConcept C112516734 @default.
- W2069773099 hasConcept C126322002 @default.
- W2069773099 hasConcept C181199279 @default.
- W2069773099 hasConcept C185592680 @default.
- W2069773099 hasConcept C2777292125 @default.
- W2069773099 hasConcept C2777444498 @default.
- W2069773099 hasConcept C2777557582 @default.
- W2069773099 hasConcept C2778775115 @default.
- W2069773099 hasConcept C2779026020 @default.
- W2069773099 hasConcept C55493867 @default.
- W2069773099 hasConcept C71924100 @default.
- W2069773099 hasConcept C89560881 @default.
- W2069773099 hasConceptScore W2069773099C112516734 @default.
- W2069773099 hasConceptScore W2069773099C126322002 @default.
- W2069773099 hasConceptScore W2069773099C181199279 @default.
- W2069773099 hasConceptScore W2069773099C185592680 @default.
- W2069773099 hasConceptScore W2069773099C2777292125 @default.
- W2069773099 hasConceptScore W2069773099C2777444498 @default.
- W2069773099 hasConceptScore W2069773099C2777557582 @default.
- W2069773099 hasConceptScore W2069773099C2778775115 @default.
- W2069773099 hasConceptScore W2069773099C2779026020 @default.
- W2069773099 hasConceptScore W2069773099C55493867 @default.
- W2069773099 hasConceptScore W2069773099C71924100 @default.
- W2069773099 hasConceptScore W2069773099C89560881 @default.
- W2069773099 hasIssue "6" @default.
- W2069773099 hasLocation W20697730991 @default.
- W2069773099 hasLocation W20697730992 @default.
- W2069773099 hasOpenAccess W2069773099 @default.
- W2069773099 hasPrimaryLocation W20697730991 @default.
- W2069773099 hasRelatedWork W1483299144 @default.
- W2069773099 hasRelatedWork W1977417712 @default.
- W2069773099 hasRelatedWork W2002041775 @default.
- W2069773099 hasRelatedWork W2066935102 @default.
- W2069773099 hasRelatedWork W2069773099 @default.
- W2069773099 hasRelatedWork W2106021441 @default.
- W2069773099 hasRelatedWork W2162221391 @default.
- W2069773099 hasRelatedWork W2224356038 @default.
- W2069773099 hasRelatedWork W2407533254 @default.
- W2069773099 hasRelatedWork W2565116432 @default.
- W2069773099 hasVolume "36" @default.
- W2069773099 isParatext "false" @default.
- W2069773099 isRetracted "false" @default.
- W2069773099 magId "2069773099" @default.
- W2069773099 workType "article" @default.