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• W2069775638 abstract "Context: The determinants of the variability in the clinical response to metformin in women with the polycystic ovary syndrome (PCOS) are enigmatic. Organic cation transporter 1 (OCT1) plays a trigger role in the hepatic uptake of metformin. In cellular studies, it was recently shown that seven polymorphisms of OCT1 exhibit reduced transport of metformin. It is noteworthy that four of the seven variants, R61C (C>T), G401S (G>A), G465R (G>A), and 420del, are present in individuals of European descent." @default.
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• W2069775638 date "2010-10-01" @default.
• W2069775638 modified "2023-10-16" @default.
• W2069775638 title "Organic Cation Transporter 1 Polymorphisms Predict the Metabolic Response to Metformin in Women with the Polycystic Ovary Syndrome" @default.
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• W2069775638 doi "https://doi.org/10.1210/jc.2010-0145" @default.
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