Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069783631> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2069783631 endingPage "303" @default.
- W2069783631 startingPage "297" @default.
- W2069783631 abstract "The human diploid fibroblast culture, WI-38 was analysed for chromosomal damage after 24 h exposures to benzo(a)pyrene (BP), 3-methylcholanthrene (MCA), n-methyl-n′-nitrosoguanidine (MNNG), 4-nitroquinoline-1-oxide (4NQO), pyrene and caffeine. A low concentration of 4NQO (0.15 μM) and MNNG (1.9 μM) produced breakage and exchange figures. A relatively high concentration of caffeine (1300 μM) caused breakage. The other compounds (BP, MCA and pyrene) caused little or no increase in damage above the control levels. A 1-h pulse exposure of WI-38 cells to BP (40 μM) in the presence of a rat liver homogenate supernate (S-9) resulted in damage significantly greater than the untreated cells or cells treated with BP alone. 4NQO (0.25 μM) produced exchange figures after a similar 1-h exposure, but this effect was eliminated by the S-9. A much higher concentration of caffeine (10, 300 μM) was required to cause breakage greater than control levels after a one hour exposure. The results indicate a possible short term in vitro human cell system for distinguishing carcinogens, procarcinogens, and noncarcinogens." @default.
- W2069783631 created "2016-06-24" @default.
- W2069783631 creator A5004109655 @default.
- W2069783631 creator A5065645132 @default.
- W2069783631 creator A5088971556 @default.
- W2069783631 date "1977-08-01" @default.
- W2069783631 modified "2023-10-17" @default.
- W2069783631 title "Chromosomal effects of carcinogens and non-carcinogens on WI-38 after short term exposures with and without metabolic activation" @default.
- W2069783631 cites W1971557513 @default.
- W2069783631 cites W1973195696 @default.
- W2069783631 cites W1979266798 @default.
- W2069783631 cites W2000890884 @default.
- W2069783631 cites W2004314923 @default.
- W2069783631 cites W2009197119 @default.
- W2069783631 cites W2041976716 @default.
- W2069783631 cites W2046105677 @default.
- W2069783631 cites W2063114453 @default.
- W2069783631 cites W2083561906 @default.
- W2069783631 cites W2132946338 @default.
- W2069783631 cites W3026311663 @default.
- W2069783631 doi "https://doi.org/10.1016/0165-1161(77)90006-1" @default.
- W2069783631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/408680" @default.
- W2069783631 hasPublicationYear "1977" @default.
- W2069783631 type Work @default.
- W2069783631 sameAs 2069783631 @default.
- W2069783631 citedByCount "24" @default.
- W2069783631 countsByYear W20697836312016 @default.
- W2069783631 crossrefType "journal-article" @default.
- W2069783631 hasAuthorship W2069783631A5004109655 @default.
- W2069783631 hasAuthorship W2069783631A5065645132 @default.
- W2069783631 hasAuthorship W2069783631A5088971556 @default.
- W2069783631 hasConcept C104317684 @default.
- W2069783631 hasConcept C114246631 @default.
- W2069783631 hasConcept C134018914 @default.
- W2069783631 hasConcept C143425029 @default.
- W2069783631 hasConcept C153911025 @default.
- W2069783631 hasConcept C178790620 @default.
- W2069783631 hasConcept C185592680 @default.
- W2069783631 hasConcept C202751555 @default.
- W2069783631 hasConcept C2777538855 @default.
- W2069783631 hasConcept C2778500429 @default.
- W2069783631 hasConcept C2778951431 @default.
- W2069783631 hasConcept C2779911484 @default.
- W2069783631 hasConcept C2780381497 @default.
- W2069783631 hasConcept C33070731 @default.
- W2069783631 hasConcept C54355233 @default.
- W2069783631 hasConcept C552990157 @default.
- W2069783631 hasConcept C55493867 @default.
- W2069783631 hasConcept C555283112 @default.
- W2069783631 hasConcept C81885089 @default.
- W2069783631 hasConcept C86803240 @default.
- W2069783631 hasConceptScore W2069783631C104317684 @default.
- W2069783631 hasConceptScore W2069783631C114246631 @default.
- W2069783631 hasConceptScore W2069783631C134018914 @default.
- W2069783631 hasConceptScore W2069783631C143425029 @default.
- W2069783631 hasConceptScore W2069783631C153911025 @default.
- W2069783631 hasConceptScore W2069783631C178790620 @default.
- W2069783631 hasConceptScore W2069783631C185592680 @default.
- W2069783631 hasConceptScore W2069783631C202751555 @default.
- W2069783631 hasConceptScore W2069783631C2777538855 @default.
- W2069783631 hasConceptScore W2069783631C2778500429 @default.
- W2069783631 hasConceptScore W2069783631C2778951431 @default.
- W2069783631 hasConceptScore W2069783631C2779911484 @default.
- W2069783631 hasConceptScore W2069783631C2780381497 @default.
- W2069783631 hasConceptScore W2069783631C33070731 @default.
- W2069783631 hasConceptScore W2069783631C54355233 @default.
- W2069783631 hasConceptScore W2069783631C552990157 @default.
- W2069783631 hasConceptScore W2069783631C55493867 @default.
- W2069783631 hasConceptScore W2069783631C555283112 @default.
- W2069783631 hasConceptScore W2069783631C81885089 @default.
- W2069783631 hasConceptScore W2069783631C86803240 @default.
- W2069783631 hasIssue "4" @default.
- W2069783631 hasLocation W20697836311 @default.
- W2069783631 hasLocation W20697836312 @default.
- W2069783631 hasOpenAccess W2069783631 @default.
- W2069783631 hasPrimaryLocation W20697836311 @default.
- W2069783631 hasRelatedWork W1964753430 @default.
- W2069783631 hasRelatedWork W1988537093 @default.
- W2069783631 hasRelatedWork W1998804945 @default.
- W2069783631 hasRelatedWork W2016471840 @default.
- W2069783631 hasRelatedWork W2035509280 @default.
- W2069783631 hasRelatedWork W2041626709 @default.
- W2069783631 hasRelatedWork W2051622237 @default.
- W2069783631 hasRelatedWork W2055821050 @default.
- W2069783631 hasRelatedWork W2065921964 @default.
- W2069783631 hasRelatedWork W2069783631 @default.
- W2069783631 hasVolume "46" @default.
- W2069783631 isParatext "false" @default.
- W2069783631 isRetracted "false" @default.
- W2069783631 magId "2069783631" @default.
- W2069783631 workType "article" @default.