FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069792406> ?p ?o ?g. }

• W2069792406 endingPage "28" @default.
• W2069792406 startingPage "18" @default.
• W2069792406 abstract "Traumatic brain injury (TBI) is a major contributor to mortality and morbidity. The pathophysiology involves development of brain edema. Therapeutic options are limited as the mechanisms are not fully understood. Changes in the function of the blood–brain barrier (BBB), as well as variations in aquaporin expression, have been proposed to be involved in the development of the edema but the contribution of each factor has not been fully elucidated. In order to evaluate these mechanisms, in a potential window of opportunity, the early dynamic response was studied using an animal model causing a moderate TBI. Sprague-Dawley rats were subjected to blunt controlled head trauma and followed for up to four days by magnetic-resonance-imaging, immunohistofluorescence, immunohistochemistry, and quantitative protein analysis. Non-traumatized animals served as controls. TBI resulted in a midline shift and a decrease in Apparent Diffusion Coefficient, indicating a hemispheric enlargement due to cytotoxic edema. The tight junction protein Zona Occludens-1 was decreased (−25%) and associated with an increased IgG permeability (+20%) in the perilesional brain tissue in accordance with a BBB breakdown. The total amount of AQP4 protein decreased (−20%). The disruption of the BBB lasted for 4 days while the impact on AQP4 levels disappeared between day 1 and 4. Our findings shows that blunt focal brain injury results in an early development of brain edema involving both cytotoxic and vasogenic components, a persistent BBB breakdown and a temporary decrease in AQP4, and indicates that both types of edemas and mechanisms should be targeted in TBI treatment. • Early coexistence of both cytotoxic and vasogenic edema in focal TBI. • ZO-1 decrease and extravasation of IgG indicate a persistent BBB breakdown. • Transient decrease of AQP4 in the perilesional area." @default.
• W2069792406 created "2016-06-24" @default.
• W2069792406 creator A5046552219 @default.
• W2069792406 creator A5071164753 @default.
• W2069792406 creator A5073953232 @default.
• W2069792406 creator A5089053932 @default.
• W2069792406 date "2015-06-01" @default.
• W2069792406 modified "2023-10-03" @default.
• W2069792406 title "Aquaporins and blood–brain barrier permeability in early edema development after traumatic brain injury" @default.
• W2069792406 cites W1495656315 @default.
• W2069792406 cites W1535419310 @default.
• W2069792406 cites W1535546167 @default.
• W2069792406 cites W1949952380 @default.
• W2069792406 cites W1964139046 @default.
• W2069792406 cites W1970826358 @default.
• W2069792406 cites W1971371653 @default.
• W2069792406 cites W1971931351 @default.
• W2069792406 cites W1972753388 @default.
• W2069792406 cites W1980829307 @default.
• W2069792406 cites W1982632034 @default.
• W2069792406 cites W1984587620 @default.
• W2069792406 cites W1987787017 @default.
• W2069792406 cites W1991328725 @default.
• W2069792406 cites W1994685484 @default.
• W2069792406 cites W1994757585 @default.
• W2069792406 cites W1995419987 @default.
• W2069792406 cites W1996279818 @default.
• W2069792406 cites W1996614758 @default.
• W2069792406 cites W1998056500 @default.
• W2069792406 cites W2000965529 @default.
• W2069792406 cites W2001613505 @default.
• W2069792406 cites W2002325164 @default.
• W2069792406 cites W2003535676 @default.
• W2069792406 cites W2003606001 @default.
• W2069792406 cites W2003890250 @default.
• W2069792406 cites W2011398156 @default.
• W2069792406 cites W2011506481 @default.
• W2069792406 cites W2016451391 @default.
• W2069792406 cites W2031275782 @default.
• W2069792406 cites W2040733706 @default.
• W2069792406 cites W2041119909 @default.
• W2069792406 cites W2043291008 @default.
• W2069792406 cites W2052322755 @default.
• W2069792406 cites W2056270913 @default.
• W2069792406 cites W2057509573 @default.
• W2069792406 cites W2064857678 @default.
• W2069792406 cites W2067692269 @default.
• W2069792406 cites W2073143007 @default.
• W2069792406 cites W2076015301 @default.
• W2069792406 cites W2076749993 @default.
• W2069792406 cites W2077832041 @default.
• W2069792406 cites W2080714912 @default.
• W2069792406 cites W2087041892 @default.
• W2069792406 cites W2093126739 @default.
• W2069792406 cites W2096230518 @default.
• W2069792406 cites W2101957440 @default.
• W2069792406 cites W2102336118 @default.
• W2069792406 cites W2105925560 @default.
• W2069792406 cites W2120679080 @default.
• W2069792406 cites W2123230988 @default.
• W2069792406 cites W2135038519 @default.
• W2069792406 cites W2142993639 @default.
• W2069792406 cites W2154108863 @default.
• W2069792406 cites W2163862018 @default.
• W2069792406 cites W2170602294 @default.
• W2069792406 cites W2316762748 @default.
• W2069792406 cites W2471407841 @default.
• W2069792406 cites W4236618431 @default.
• W2069792406 cites W4361980455 @default.
• W2069792406 doi "https://doi.org/10.1016/j.brainres.2015.03.004" @default.
• W2069792406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25770057" @default.
• W2069792406 hasPublicationYear "2015" @default.
• W2069792406 type Work @default.
• W2069792406 sameAs 2069792406 @default.
• W2069792406 citedByCount "50" @default.
• W2069792406 countsByYear W20697924062015 @default.
• W2069792406 countsByYear W20697924062016 @default.
• W2069792406 countsByYear W20697924062017 @default.
• W2069792406 countsByYear W20697924062018 @default.
• W2069792406 countsByYear W20697924062019 @default.
• W2069792406 countsByYear W20697924062020 @default.
• W2069792406 countsByYear W20697924062021 @default.
• W2069792406 countsByYear W20697924062022 @default.
• W2069792406 crossrefType "journal-article" @default.
• W2069792406 hasAuthorship W2069792406A5046552219 @default.
• W2069792406 hasAuthorship W2069792406A5071164753 @default.
• W2069792406 hasAuthorship W2069792406A5073953232 @default.
• W2069792406 hasAuthorship W2069792406A5089053932 @default.
• W2069792406 hasConcept C10162356 @default.
• W2069792406 hasConcept C118552586 @default.
• W2069792406 hasConcept C126322002 @default.
• W2069792406 hasConcept C126838900 @default.
• W2069792406 hasConcept C134018914 @default.
• W2069792406 hasConcept C142724271 @default.
• W2069792406 hasConcept C143409427 @default.
• W2069792406 hasConcept C15755913 @default.
• W2069792406 hasConcept C177779419 @default.
• W2069792406 hasConcept C2778402981 @default.

• next