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- W2069802021 abstract "A number of aliphatic primary amines were tested for their effects on the growth of ras-transformed NIH 3T3 cells (PAP2 cells), as measured by incorporation of tritiated thymidine into DNA. Long-chain, saturated amines (C12 to C18) were growth inhibitory, whereas short-chain amines (C6, C8) were not. Farnesylamine, a branched-chain, unsaturated amine (C15), had an ic50 of 6.9 μM compared to ic501050 values of 13.1 to 45.8 μM for straight-chain, saturated amines. Oleylamine, with an ic50 of 0.1 μM, was the most potent inhibitor. The long-chain amines, but not the short-chain amines, were also effective inhibitors of protein kinase C, assayed in vitro in a cell-free system. In addition, studies with indo-1-loaded PAP2 cells showed that long-chain amines induced a reversible rise in intracellular free Ca2+ concentration. Growth inhibition by the amines was positively correlated with this effect, suggesting that factors other than protein kinase C may be involved in the inhibition of growth of PAP2 cells by long-chain amines." @default.
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- W2069802021 date "1994-05-01" @default.
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- W2069802021 title "Effects of long-chain fatty amines on the growth of ras-transformed NIH 3T3 cells" @default.
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- W2069802021 doi "https://doi.org/10.1016/0006-2952(94)90322-0" @default.
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