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• W2069808350 endingPage "112" @default.
• W2069808350 startingPage "106" @default.
• W2069808350 abstract "Microglia are the resident phagocytic cells of the central nervous system. During brain development they are also imperative for apoptosis of excessive neurons, synaptic pruning, phagocytosis of debris and maintaining brain homeostasis. Brain damage results in a fast and dynamic microglia reaction, which can influence the extent and distribution of subsequent neuronal dysfunction. As a consequence, microglia responses can promote tissue protection and repair following brain injury, or become detrimental for the tissue integrity and functionality. In this review, we will describe microglia responses in the human developing brain in association with injury, with particular focus on the preterm infant. We also explore microglia responses and mechanisms of microglia toxicity in animal models of preterm white matter injury and in vitro primary microglia cell culture experiments." @default.
• W2069808350 created "2016-06-24" @default.
• W2069808350 creator A5028249851 @default.
• W2069808350 creator A5030623189 @default.
• W2069808350 creator A5072834295 @default.
• W2069808350 creator A5085000043 @default.
• W2069808350 date "2014-09-01" @default.
• W2069808350 modified "2023-10-14" @default.
• W2069808350 title "Microglia toxicity in preterm brain injury" @default.
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