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• W2069814568 abstract "Abstract. Purpose: Photodynamic riboflavin/ultraviolet‐A (UVA)‐induced collagen cross‐linking, which increases the biomechanical stiffness of the human cornea by about 300%, has been introduced recently as a possible treatment for progressive keratoconus. The present study was undertaken to evaluate the longterm biomechanical effects of this new cross‐linking treatment as a necessary prerequisite to its clinical success. Methods: The corneas of the left eyes of nine male rabbits were cross‐linked. The contralateral eyes served as controls. After removal of the central 7 mm of the epithelium, the corneas were treated with the photosensitizer riboflavin and UVA irradiation for 30 mins with an irradiance of 3 mW/cm 2 using a 370‐nm UVA double diode. Groups of three animals were killed immediately after treatment and at 3 and 8 months, respectively. Biomechanical stress–strain measurements were performed using a microcomputer‐controlled biomaterial tester on 4 × 10‐mm corneal strips. Results: Corneal thickness in the treated rabbit cornea was 408 ± 20 μm. A constant and significant increase in ultimate stress (of 69.7–106.0%), Young’s modulus of elasticity (of 78.4–87.4%) and a decrease in ultimate strain (of 0.57–78.4%) were found over a time period of up to 8 months after cross‐linking treatment. Conclusions: Riboflavin/UVA‐induced collagen cross‐linking leads to a longterm increase in biomechanical rigidity which remains stable over time. These data support our previous longterm clinical observations and give hope that this new treatment will halt progressive keratoconus definitively." @default.
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• W2069814568 date "2009-01-27" @default.
• W2069814568 modified "2023-10-18" @default.
• W2069814568 title "Long-term biomechanical properties of rabbit cornea after photodynamic collagen crosslinking" @default.
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• W2069814568 doi "https://doi.org/10.1111/j.1755-3768.2008.01190.x" @default.
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